产品
编 号：F022956
分子式：C20H21N7O7
分子量：471.42
分子式：C20H21N7O7
分子量：471.42
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
询价
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5mg
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10mg
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25mg
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结构图
CAS No: 10538-99-5
产品详情
生物活性：
LY 345899 is a Folate analog and is a methylene tetrahydrofolate dehydrogenase (MTHFD1; DC301) and MTHFD2 inbhibitor with IC50 values of 96 nM and 663 nM, respectively and a Ki of 18 nM for MTHFD1.
体内研究：
LY345899 (Intraperitoneal injection; 5-10 mg/kg; 5 d/wk; 4 weeks) shows potent antitumor activity and displays therapeutic activity against CRC in vivo.Animal Model:SW620 or PDX-based BABL/c nude colorectal cancer (CRC) model
Dosage:5-10 mg/kg
Administration:Intraperitoneal injection; 5-10 mg/kg; 5 d/wk; 4 weeks
Result:Displayed lower cell proliferation indices and higher cell apoptosis.Exhibited no statistically significant weight loss or other signs of acute or delayed toxicity in mice.
体外研究：
LY 345899 could suppress the MTHFD enzyme in the cytoplasm and mitochondria.?LY 345899 could disturb the NADPH and redox homeostases and accelerate cell death under oxidative stress, such as hypoxia, or causing in vitro anchorage independence and in vivo impaired tumor growth and metastasis.
LY 345899 is a Folate analog and is a methylene tetrahydrofolate dehydrogenase (MTHFD1; DC301) and MTHFD2 inbhibitor with IC50 values of 96 nM and 663 nM, respectively and a Ki of 18 nM for MTHFD1.
体内研究：
LY345899 (Intraperitoneal injection; 5-10 mg/kg; 5 d/wk; 4 weeks) shows potent antitumor activity and displays therapeutic activity against CRC in vivo.Animal Model:SW620 or PDX-based BABL/c nude colorectal cancer (CRC) model
Dosage:5-10 mg/kg
Administration:Intraperitoneal injection; 5-10 mg/kg; 5 d/wk; 4 weeks
Result:Displayed lower cell proliferation indices and higher cell apoptosis.Exhibited no statistically significant weight loss or other signs of acute or delayed toxicity in mice.
体外研究：
LY 345899 could suppress the MTHFD enzyme in the cytoplasm and mitochondria.?LY 345899 could disturb the NADPH and redox homeostases and accelerate cell death under oxidative stress, such as hypoxia, or causing in vitro anchorage independence and in vivo impaired tumor growth and metastasis.
产品资料
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