产品
编 号：F193973
分子式：C17H18N3NaO3S
分子量：367.4
分子式：C17H18N3NaO3S
分子量：367.4
产品类型
规格
价格
是否有货
1mg
175
In-stock
5mg
350
In-stock
10mg
560
In-stock
50mg
1200
In-stock
100mg
1560
In-stock
250mg
2360
In-stock
结构图
CAS No: 161796-78-7
产品详情
生物活性：
Esomeprazole sodium ((S)-Omeprazole sodium) is a potent and orally active proton pump inhibitor. Esomeprazole reduces acid secretion through inhibition of the H+, K+-ATPase in gastric parietal cells. Esomeprazole acts as an exosome inhibitor by blocking the exosome release via the inhibition of V-H+-ATPases. Esomeprazole has the potential for symptomatic gastroesophageal reflux disease research.
体内研究：
Esomeprazole (30-300 mg/kg; oral gavage; daily; for 19 or 11 days; C57BL/6J mice) treatment significantly inhibits the progression of fibrosis throughout the lungs of the animals. Esomeprazole also reduces circulating markers of inflammation and fibrosis.Animal Model:C57BL/6J mice (8-weeks old, 25-30 g) treated with cotton smoke-induced lung injury
Dosage:30 mg/kg, 300 mg/kg
Administration:Oral gavage; daily; for 19 or 11 days
Result:Significantly inhibited the progression of fibrosis throughout the lungs of the animals.
体外研究：
Esomeprazole (25-100 μM; 20 hours; MDA-MB-468 cells) treatment suppresses growth of triple-negative breast cancer cell in vitro in a dose-dependent manner through increase in their intracellular acidification.
Esomeprazole sodium ((S)-Omeprazole sodium) is a potent and orally active proton pump inhibitor. Esomeprazole reduces acid secretion through inhibition of the H+, K+-ATPase in gastric parietal cells. Esomeprazole acts as an exosome inhibitor by blocking the exosome release via the inhibition of V-H+-ATPases. Esomeprazole has the potential for symptomatic gastroesophageal reflux disease research.
体内研究：
Esomeprazole (30-300 mg/kg; oral gavage; daily; for 19 or 11 days; C57BL/6J mice) treatment significantly inhibits the progression of fibrosis throughout the lungs of the animals. Esomeprazole also reduces circulating markers of inflammation and fibrosis.Animal Model:C57BL/6J mice (8-weeks old, 25-30 g) treated with cotton smoke-induced lung injury
Dosage:30 mg/kg, 300 mg/kg
Administration:Oral gavage; daily; for 19 or 11 days
Result:Significantly inhibited the progression of fibrosis throughout the lungs of the animals.
体外研究：
Esomeprazole (25-100 μM; 20 hours; MDA-MB-468 cells) treatment suppresses growth of triple-negative breast cancer cell in vitro in a dose-dependent manner through increase in their intracellular acidification.
产品资料
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