产品
编 号：F193944
分子式：C30H48O
分子量：424.7
分子式：C30H48O
分子量：424.7
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
结构图
CAS No: 1617-70-5
产品详情
生物活性：
Lupenone is an orally active lupine-type triterpenoid that can be isolated from Musa basjoo. Lupenone Lupenone plays a role through the PI3K/Akt/mTOR and NF-κB signaling pathways. Lupenone has anti-inflammatory, antiviral, antidiabetic and anticancer activities.
体内研究：
Lupenone (6, 12, 24 mg/kg/day, 灌胃, 连续 6 周) 通过调节 NF-κB 通路介导的炎症和 TGF-β1/Smad/ CTGF 相关纤维化改善 2 型糖尿病肾病。Animal Model:Spontaneous type 2 diabetic nephropathy db/db mouse models
Dosage:6, 12, 24 mg/kg
Administration:i.g.
Result:Maintained the fasting blood glucose.Reduced glycosylated hemoglobin, insulin, and 24 h proteinuria levels.Regulated changes in biochemical indicators
体外研究：
Lupenone (40 μM, 1 h) 通过 PI3K/Akt/mTOR 信号通路保护神经母细胞瘤 SH-SY5y 细胞免受甲基苯丙胺诱导的凋亡细胞死亡。
Lupenone is an orally active lupine-type triterpenoid that can be isolated from Musa basjoo. Lupenone Lupenone plays a role through the PI3K/Akt/mTOR and NF-κB signaling pathways. Lupenone has anti-inflammatory, antiviral, antidiabetic and anticancer activities.
体内研究：
Lupenone (6, 12, 24 mg/kg/day, 灌胃, 连续 6 周) 通过调节 NF-κB 通路介导的炎症和 TGF-β1/Smad/ CTGF 相关纤维化改善 2 型糖尿病肾病。Animal Model:Spontaneous type 2 diabetic nephropathy db/db mouse models
Dosage:6, 12, 24 mg/kg
Administration:i.g.
Result:Maintained the fasting blood glucose.Reduced glycosylated hemoglobin, insulin, and 24 h proteinuria levels.Regulated changes in biochemical indicators
体外研究：
Lupenone (40 μM, 1 h) 通过 PI3K/Akt/mTOR 信号通路保护神经母细胞瘤 SH-SY5y 细胞免受甲基苯丙胺诱导的凋亡细胞死亡。
产品资料
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