产品
编 号：F193880
分子式：C20H30N2O4
分子量：362.46
分子式：C20H30N2O4
分子量：362.46
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
询价
询价
2mg
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 161710-10-7
产品详情
生物活性：
Z-Ile-Leu-aldehyde (Z-IL-CHO) is a potent and competitive peptide aldehyde inhibitor of γ-secretase and notch.
体内研究：
Z-Ile-Leu-aldehyde (GSI XII, 10?mg/kg, Intraperitoneally either for 14 days) controls myeloma bone disease mainly by targeting Notch in MM cells and possibly in osteoclasts in their microenvironment.Animal Model:MOPC315.BM mouse model.
Dosage:10?mg/kg.
Administration:Intraperitoneally either for 14 days.
Result:Reduces myeloma-specific paraprotein levels in the MOPC315.BM model.Diminished osteolytic lesions in the MOPC315.BM mice.
体外研究：
Z-Ile-Leu-aldehyde (ILCHO) significantly downregulates Th17-associated cytokine levels in murine Th17 in vitro polarization assays. Z-Ile-Leu-aldehyde (GSI XII) induces apoptosis of murine MOPC315.BM myeloma cells with high Notch activity.
Z-Ile-Leu-aldehyde (Z-IL-CHO) is a potent and competitive peptide aldehyde inhibitor of γ-secretase and notch.
体内研究：
Z-Ile-Leu-aldehyde (GSI XII, 10?mg/kg, Intraperitoneally either for 14 days) controls myeloma bone disease mainly by targeting Notch in MM cells and possibly in osteoclasts in their microenvironment.Animal Model:MOPC315.BM mouse model.
Dosage:10?mg/kg.
Administration:Intraperitoneally either for 14 days.
Result:Reduces myeloma-specific paraprotein levels in the MOPC315.BM model.Diminished osteolytic lesions in the MOPC315.BM mice.
体外研究：
Z-Ile-Leu-aldehyde (ILCHO) significantly downregulates Th17-associated cytokine levels in murine Th17 in vitro polarization assays. Z-Ile-Leu-aldehyde (GSI XII) induces apoptosis of murine MOPC315.BM myeloma cells with high Notch activity.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备