产品
编 号：F193747
分子式：C16H15Cl2NO3
分子量：340.2
分子式：C16H15Cl2NO3
分子量：340.2
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CAS No: 1616271-41-0
产品详情
生物活性：
CCTA-1523 is a potent, selective, reversible and orally active ABCG2 inhibitor. CCTA-1523 shows cytotoxicity. CCTA-1523 shows anticancer activity.
体内研究：
CCTA-1523 (75 mg/kg；口服；q3d x 6) 与阿霉素 (HY-15142A) (1.8 mg/kg，腹腔注射，q3d X 6) 联合使用可抑制肿瘤生长并延长小鼠的生存时间。Animal Model:NCR nude mice (H460/MX20 xenografts)
Dosage:75 mg/kg (DOX ;1.8 mg/kg, i.p., q3d X 6)
Administration:P.o.;q3d x 6
Result:Significantly inhibited the growth of H460/MX20 tumor xenografts when combined with doxorubicin compared to the vehicle control group.
体外研究：
CCTA-1523 (0-1000 μM；72 小时) 对 H460、H460/MX20、HEK293/pcDNA3.1、HEK/R482、HEK/R482G 和 HEK/R482T 细胞具有细胞毒性。
CCTA-1523 is a potent, selective, reversible and orally active ABCG2 inhibitor. CCTA-1523 shows cytotoxicity. CCTA-1523 shows anticancer activity.
体内研究：
CCTA-1523 (75 mg/kg；口服；q3d x 6) 与阿霉素 (HY-15142A) (1.8 mg/kg，腹腔注射，q3d X 6) 联合使用可抑制肿瘤生长并延长小鼠的生存时间。Animal Model:NCR nude mice (H460/MX20 xenografts)
Dosage:75 mg/kg (DOX ;1.8 mg/kg, i.p., q3d X 6)
Administration:P.o.;q3d x 6
Result:Significantly inhibited the growth of H460/MX20 tumor xenografts when combined with doxorubicin compared to the vehicle control group.
体外研究：
CCTA-1523 (0-1000 μM；72 小时) 对 H460、H460/MX20、HEK293/pcDNA3.1、HEK/R482、HEK/R482G 和 HEK/R482T 细胞具有细胞毒性。
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