产品
编 号：F193512
分子式：C11H18Cl2N2O
分子量：265.18
分子式：C11H18Cl2N2O
分子量：265.18
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
50mg
询价
询价
结构图
CAS No: 161416-61-1
产品详情
生物活性：
Pozanicline dihydrochloride (ABT-089 dihydrochloride) is an orally bioavailable nicotinic acetylcholine receptor (nAChR) agonist with a Ki of 16.7 nM for binding to [3H]cytisine sites. Pozanicline is an α4β2-selective nAChR agonist, which binds to rat brain α4β2 nAChR with a Ki of 17 nM while binding to α7 nAChR is insignificant.
体内研究：
Pozanicline (ABT-089; 0.3 mg/kgand0.6 mg/kg) reverses nicotine withdrawal-induced deficits in contextual fear conditioning.Animal Model:Adult male C57BL6/J mice at 8-12 weeks of age.
Dosage:0.3 mg/kg and 0.6 mg/kg
Administration:Treated 5 min before training and testing for contextual fear conditioning
Result:A dose of0.3 mg/kg and0.6 mg/kg ameliorated nicotine withdrawal-induced cognitive deficits in contextual fear conditioning.
体外研究：
Pozanicline (ABT-089) is a partial agonist at α4β2 nAChR. Moreover, one α6β2 nAChR subtype is particularly sensitive to Pozanicline with an EC50 of 0.11 μM. Pozanicline (ABT-089) shows high selectivity for α6β2 and α4α5β2 nAChR subtypes.
Pozanicline dihydrochloride (ABT-089 dihydrochloride) is an orally bioavailable nicotinic acetylcholine receptor (nAChR) agonist with a Ki of 16.7 nM for binding to [3H]cytisine sites. Pozanicline is an α4β2-selective nAChR agonist, which binds to rat brain α4β2 nAChR with a Ki of 17 nM while binding to α7 nAChR is insignificant.
体内研究：
Pozanicline (ABT-089; 0.3 mg/kgand0.6 mg/kg) reverses nicotine withdrawal-induced deficits in contextual fear conditioning.Animal Model:Adult male C57BL6/J mice at 8-12 weeks of age.
Dosage:0.3 mg/kg and 0.6 mg/kg
Administration:Treated 5 min before training and testing for contextual fear conditioning
Result:A dose of0.3 mg/kg and0.6 mg/kg ameliorated nicotine withdrawal-induced cognitive deficits in contextual fear conditioning.
体外研究：
Pozanicline (ABT-089) is a partial agonist at α4β2 nAChR. Moreover, one α6β2 nAChR subtype is particularly sensitive to Pozanicline with an EC50 of 0.11 μM. Pozanicline (ABT-089) shows high selectivity for α6β2 and α4α5β2 nAChR subtypes.
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