产品
编 号：F193461
分子式：C19H16N2O2S
分子量：336.41
分子式：C19H16N2O2S
分子量：336.41
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
2mg
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5mg
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10mg
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50mg
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询价
结构图
CAS No: 1613710-01-2
产品详情
生物活性：
ARN-3236 is an oral active and selective inhibitor of salt-inducible kinase 2 (SIK2), with IC50s of <1 nM, 21.63 nM and 6.63 nM for SIK2, SIK1 and SIK3, respectively. Has anti-cancer activity.
体内研究：
ARN-3236 (60 mg/kg, orally) sensitizes ovarian cancer to NSC 125973 in vivo.Animal Model:SKOv3ip-bearing mice and OVCAR8-bearing mice.
Dosage:60 mg/kg.
Administration:Orally once daily for 3 weeks (SKOv3ip-bearing mice) and 4 weeks (OVCAR8-bearing mice).
Result:Sensitized ovarian cancer to NSC 125973.
体外研究：
ARN-3236 inhibits SIK2 activity with an IC50 ARN-3236 相关抗体:Cell Viability AssayCell Line:HEY and A2780 human ovarian cancer cell lines.
Concentration:0-10 μM.
Incubation Time:24 hours.
Result:Inhibited SIK2 activity with an IC50 <1 nM.
ARN-3236 is an oral active and selective inhibitor of salt-inducible kinase 2 (SIK2), with IC50s of <1 nM, 21.63 nM and 6.63 nM for SIK2, SIK1 and SIK3, respectively. Has anti-cancer activity.
体内研究：
ARN-3236 (60 mg/kg, orally) sensitizes ovarian cancer to NSC 125973 in vivo.Animal Model:SKOv3ip-bearing mice and OVCAR8-bearing mice.
Dosage:60 mg/kg.
Administration:Orally once daily for 3 weeks (SKOv3ip-bearing mice) and 4 weeks (OVCAR8-bearing mice).
Result:Sensitized ovarian cancer to NSC 125973.
体外研究：
ARN-3236 inhibits SIK2 activity with an IC50 ARN-3236 相关抗体:Cell Viability AssayCell Line:HEY and A2780 human ovarian cancer cell lines.
Concentration:0-10 μM.
Incubation Time:24 hours.
Result:Inhibited SIK2 activity with an IC50 <1 nM.
产品资料
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