产品
编 号：F193397
分子式：C40H38ClN5O
分子量：640.22
分子式：C40H38ClN5O
分子量：640.22
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
2mg
询价
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5mg
询价
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10mg
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50mg
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询价
结构图
CAS No: 1613404-76-4
产品详情
生物活性：
Deltarasin hydrochloride is an inhibitor of?KRAS-PDEδinteraction with?Kd?of 38 nM for binding to purified PDEδ.
体内研究：
Deltarasin (10 mg/kg, i.p.) impairs dose-dependent tumor growth in nude mice bearing subcutaneous human Panc-Tu-I tumour cell xenografts.
体外研究：
In liver cells, deltarasin inhibits the interaction of RAS with PDEδ with KD?of 41 nM. Inhibition of PDEδ-KRAS interaction by deltarasin suppresses proliferation of human pancreatic ductal adenocarcinoma cells that are dependent on oncogenic KRAS.
Deltarasin hydrochloride is an inhibitor of?KRAS-PDEδinteraction with?Kd?of 38 nM for binding to purified PDEδ.
体内研究：
Deltarasin (10 mg/kg, i.p.) impairs dose-dependent tumor growth in nude mice bearing subcutaneous human Panc-Tu-I tumour cell xenografts.
体外研究：
In liver cells, deltarasin inhibits the interaction of RAS with PDEδ with KD?of 41 nM. Inhibition of PDEδ-KRAS interaction by deltarasin suppresses proliferation of human pancreatic ductal adenocarcinoma cells that are dependent on oncogenic KRAS.
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