产品
编 号：F022100
分子式：C35H59N9O13
分子量：813.9
分子式：C35H59N9O13
分子量：813.9
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CAS No: 105184-37-0
产品详情
生物活性：
Splenopentin diacetate is a synthetic immunomodulating pentapeptide corresponding to the residues 32-36 of the splenic hormone splenin. Splenopentin diacetate influences both early T and B cell differentiation, to increase the number of antibody-forming cells in mice after gamma irradiation.
体内研究：
Splenopentin (1 mg/kg; i.p. three times a week for 7-90 d) accelerates Langerhans cell recruitment and leads to pretreatment levels of Langerhans cell (LC) density in the skin of mice.Splenopentin (0.01-100 μg per mouse; i.p.) has no demonstrable effect on neuromuscular transmission of mice.Animal Model:Female Balb/c/Bln mice were injected Cyclophosphamide or Dexamethasone for 5 consecutive days
Dosage:1 mg/kg
Administration:I.p. three times a week for 7-90 days
Result:Reached the normal number of epidermal LCs at 28 days after the beginning of Cyclophosphamide treatment.Accelerated restoration process and reached the normal LC density in the skin after 70 days in Dexamethasone treatment grops.
体外研究：
Splenopentin (1-100 μM) augments human NK cells and has no cytotoxicity.Splenopentin (0.1 ng/mL-10 μg/mL; 3 h) induces phenotypic differentiation of both T- and B-cell precursor cells.
Splenopentin diacetate is a synthetic immunomodulating pentapeptide corresponding to the residues 32-36 of the splenic hormone splenin. Splenopentin diacetate influences both early T and B cell differentiation, to increase the number of antibody-forming cells in mice after gamma irradiation.
体内研究：
Splenopentin (1 mg/kg; i.p. three times a week for 7-90 d) accelerates Langerhans cell recruitment and leads to pretreatment levels of Langerhans cell (LC) density in the skin of mice.Splenopentin (0.01-100 μg per mouse; i.p.) has no demonstrable effect on neuromuscular transmission of mice.Animal Model:Female Balb/c/Bln mice were injected Cyclophosphamide or Dexamethasone for 5 consecutive days
Dosage:1 mg/kg
Administration:I.p. three times a week for 7-90 days
Result:Reached the normal number of epidermal LCs at 28 days after the beginning of Cyclophosphamide treatment.Accelerated restoration process and reached the normal LC density in the skin after 70 days in Dexamethasone treatment grops.
体外研究：
Splenopentin (1-100 μM) augments human NK cells and has no cytotoxicity.Splenopentin (0.1 ng/mL-10 μg/mL; 3 h) induces phenotypic differentiation of both T- and B-cell precursor cells.
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