产品
编 号：F190617
分子式：C21H21BrN2O3
分子量：429.31
分子式：C21H21BrN2O3
分子量：429.31
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
382
In-stock
5mg
840
In-stock
10mg
1440
In-stock
50mg
4640
In-stock
100mg
7360
In-stock
结构图
CAS No: 1599432-08-2
产品详情
生物活性：
NIBR189 is an EBI2 (Epstein-Barr virus-induced gene 2) antagonist. NIBR189 inhibits human and mouse EBI2 with IC50s of 11 and 16 nM, respectively. NIBR189 can be used for the research of autoimmune diseases.
体内研究：
1.19Pharmacokinetic Properties of NIBR189 in Mice. MiceIV 1 mg/kgMicePO 3 mg/kg
CL (μL/min/mg)16
t1/2 (h)1.1
Vss (L/kg)1.4
AUC (nmol·h/L)24353608
Cmax (nmol/L) 835
tmax (h) 1
F (%) 49
体外研究：
NIBR189 (0-1 μM; 3 h) blocks migration of U937 cells.NIBR189 (0-10 μM) blocks oxysterol-dependent activation with an IC50 value of 9 nM.
NIBR189 is an EBI2 (Epstein-Barr virus-induced gene 2) antagonist. NIBR189 inhibits human and mouse EBI2 with IC50s of 11 and 16 nM, respectively. NIBR189 can be used for the research of autoimmune diseases.
体内研究：
1.19Pharmacokinetic Properties of NIBR189 in Mice. MiceIV 1 mg/kgMicePO 3 mg/kg
CL (μL/min/mg)16
t1/2 (h)1.1
Vss (L/kg)1.4
AUC (nmol·h/L)24353608
Cmax (nmol/L) 835
tmax (h) 1
F (%) 49
体外研究：
NIBR189 (0-1 μM; 3 h) blocks migration of U937 cells.NIBR189 (0-10 μM) blocks oxysterol-dependent activation with an IC50 value of 9 nM.
产品资料
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