产品
编 号：F190335
分子式：C35H56N6O5
分子量：640.86
分子式：C35H56N6O5
分子量：640.86
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CAS No: 159776-69-9
产品详情
生物活性：
Cemadotin (LU103793) is an analogue of Dolastatin 15 (HY-P1126) which is naturally occurring cytotoxic peptides. Cemadotin blocks cells at mitosis, and exhibits Ki value of 1 μM for inhibiting tubulin. Cemadotin can be used to research anticancer.
体外研究：
Cemadotin (0-100 μM; 35 min) inhibits polymerization dose-dependently in Tubulin-treated Strongylocentrotus purpuratus.Cemadotin (0-1000 nM) preferentially suppresses the rate and extent of growing excursions of tubulin, and suppression is dependent upon the drug concentration.Cemadotin (0-1 μM) markedly increases the rescue frequency but had little effect on the catastrophe frequency.Cemadotin (400 pM~300 nM; 72 h) inhibits cancer cells HEK 293, F9 and HL60.
Cemadotin (LU103793) is an analogue of Dolastatin 15 (HY-P1126) which is naturally occurring cytotoxic peptides. Cemadotin blocks cells at mitosis, and exhibits Ki value of 1 μM for inhibiting tubulin. Cemadotin can be used to research anticancer.
体外研究：
Cemadotin (0-100 μM; 35 min) inhibits polymerization dose-dependently in Tubulin-treated Strongylocentrotus purpuratus.Cemadotin (0-1000 nM) preferentially suppresses the rate and extent of growing excursions of tubulin, and suppression is dependent upon the drug concentration.Cemadotin (0-1 μM) markedly increases the rescue frequency but had little effect on the catastrophe frequency.Cemadotin (400 pM~300 nM; 72 h) inhibits cancer cells HEK 293, F9 and HL60.
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