产品
编 号：F190331
分子式：C49H75N15O12S
分子量：1098.28
分子式：C49H75N15O12S
分子量：1098.28
产品类型
规格
价格
是否有货
1mg
询价
询价
结构图
CAS No: 159768-75-9
产品详情
生物活性：
Lobradimil (RMP 7), a synthetic bradykinin analog, is a potent and selective bradykinin B2 receptor agonist (Ki: 0.54 nM). Lobradimil increases the permeability of the BBB. Lobradimil can be used in the research of brain tumors.
体内研究：
Lobradimil (2.5-mg/kg bolus plus 10 mg/kg/h for 90 minutes) increases brain tumor permeability and shows hypotensive effects in RG2 glioma cells-implanted rats.Animal Model:RG2 glioma cells-implanted rats
Dosage:1.5-18 μg/kg
Administration:i.v. infusion, 0.05 mL/min for 15min
Result:Increased Carboplatin (HY-17393) uptake (up to 80%) into brain tumors in a dose-dependent manner.
体外研究：
Lobradimil induces an increase in intracellular free calcium levels in RBME cells.Lobradimil (0.01-0.5 nM, 15 min) increases the permeability of human brain microvascular endothelial cell (HMBEC) monolayers1.
Lobradimil (RMP 7), a synthetic bradykinin analog, is a potent and selective bradykinin B2 receptor agonist (Ki: 0.54 nM). Lobradimil increases the permeability of the BBB. Lobradimil can be used in the research of brain tumors.
体内研究：
Lobradimil (2.5-mg/kg bolus plus 10 mg/kg/h for 90 minutes) increases brain tumor permeability and shows hypotensive effects in RG2 glioma cells-implanted rats.Animal Model:RG2 glioma cells-implanted rats
Dosage:1.5-18 μg/kg
Administration:i.v. infusion, 0.05 mL/min for 15min
Result:Increased Carboplatin (HY-17393) uptake (up to 80%) into brain tumors in a dose-dependent manner.
体外研究：
Lobradimil induces an increase in intracellular free calcium levels in RBME cells.Lobradimil (0.01-0.5 nM, 15 min) increases the permeability of human brain microvascular endothelial cell (HMBEC) monolayers1.
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