产品
编 号：F189955
分子式：C23H27Cl2N3O2
分子量：448.39
分子式：C23H27Cl2N3O2
分子量：448.39
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
结构图
CAS No: 159533-25-2
产品详情
生物活性：
GR 55562 (dihydrochloride) is a selective 5-HT1B receptor antagonist. GR 55562 can be used for the research of nerve disease.
体内研究：
GR 55562 (0.1-10 μg/side) 进入伏隔子区域不会引起cocaine杠杆响应。GR 55562 (0.1-10 μg/side)（伏核壳或核中）的未能调节cocaine（5 mg/kg）的辨别作用。GR 55562 (1 μg/side) 显着减弱了对cocaine的辨别作用。Animal Model:Male Wistar rats (280-300 g; n=50).
Dosage:0.1-10 μg/side
Administration:Injected intracranially; At a volume of 0.2 μl/side
Result:Did not evoke substitution for the drug with intra-accumbal shell infusion.Did not significantly affect the discriminative stimulus effects produced by 5 mg/kg of cocaine.GR 55562 (1 μg/side) attenuated the enhancement of cocaine discrimination evoked by a combination of intra-accumbalcore CP 93129 (1 μg/side) and systemic cocaine (1.25 mg/kg or 2.5 mg/kg).
GR 55562 (dihydrochloride) is a selective 5-HT1B receptor antagonist. GR 55562 can be used for the research of nerve disease.
体内研究：
GR 55562 (0.1-10 μg/side) 进入伏隔子区域不会引起cocaine杠杆响应。GR 55562 (0.1-10 μg/side)（伏核壳或核中）的未能调节cocaine（5 mg/kg）的辨别作用。GR 55562 (1 μg/side) 显着减弱了对cocaine的辨别作用。Animal Model:Male Wistar rats (280-300 g; n=50).
Dosage:0.1-10 μg/side
Administration:Injected intracranially; At a volume of 0.2 μl/side
Result:Did not evoke substitution for the drug with intra-accumbal shell infusion.Did not significantly affect the discriminative stimulus effects produced by 5 mg/kg of cocaine.GR 55562 (1 μg/side) attenuated the enhancement of cocaine discrimination evoked by a combination of intra-accumbalcore CP 93129 (1 μg/side) and systemic cocaine (1.25 mg/kg or 2.5 mg/kg).
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