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CAS No: 159445-64-4
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生物活性：
Odulimomab (anti-LFA1) is an anti-LFA-1 monoclonal antibody. Odulimomab inhibits proliferation of T lymphocyte and shows protective effects against ischemia and reperfusion injury. Odulimomab can be used for the research of transplant rejection and immunological disease.
体内研究：
Odulimomab (1.5 和 0.75 mg/kg；腹腔注射，第 1 次处理 1.5 mg/kg，然后每天注射 0.75 mg/kg) 对缺血和再灌注损伤有保护作用，对移植后肾功能有所修复。Animal Model:Cynomolgus Monkeys with renal damage ischemia and kidney autotransplantation
Dosage:1.5 and 0.75 mg/kg
Administration:Intraperitoneal injection; 1.5 mg/kg for the first dose and after pedicle clamping followed by daily injection of 0.75 mg/kg until sacrifice
Result:Decreased the creatinine level after ischemia and autotransplantation for 3 days and increased the potassium fraction reabsorption.
体外研究：
Odulimomab 在体外抑制 T 淋巴细胞增殖，以及 T 和自然杀伤细胞 (NK) 的细胞毒性和抗体产生。
Odulimomab (anti-LFA1) is an anti-LFA-1 monoclonal antibody. Odulimomab inhibits proliferation of T lymphocyte and shows protective effects against ischemia and reperfusion injury. Odulimomab can be used for the research of transplant rejection and immunological disease.
体内研究：
Odulimomab (1.5 和 0.75 mg/kg；腹腔注射，第 1 次处理 1.5 mg/kg，然后每天注射 0.75 mg/kg) 对缺血和再灌注损伤有保护作用，对移植后肾功能有所修复。Animal Model:Cynomolgus Monkeys with renal damage ischemia and kidney autotransplantation
Dosage:1.5 and 0.75 mg/kg
Administration:Intraperitoneal injection; 1.5 mg/kg for the first dose and after pedicle clamping followed by daily injection of 0.75 mg/kg until sacrifice
Result:Decreased the creatinine level after ischemia and autotransplantation for 3 days and increased the potassium fraction reabsorption.
体外研究：
Odulimomab 在体外抑制 T 淋巴细胞增殖，以及 T 和自然杀伤细胞 (NK) 的细胞毒性和抗体产生。
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