产品
编 号：F021979
分子式：C84H118N24O21S2
分子量：1864.11
分子式：C84H118N24O21S2
分子量：1864.11
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CAS No: 1051366-32-5
产品详情
生物活性：
Balixafortide (POL6326) is a potent, selective, well-tolerated peptidic CXCR4 antagonist with an IC50 < 10 nM. Balixafortide shows 1000-fold selective for CXCR4 than a large panel of receptors including CXCR7. Balixafortide blocks β-arrestin recruitment and calcium flux with IC50s < 10 nM. Balixafortide is also a potent hematopoietic stem and progenitor cell (HSPC) mobilizing agent. Anti-cancer effects.
体内研究：
Balixafortide is optimized for favorable mouse absorption, distribution, metabolism and excretion (ADME) properties with balanced plasma protein binding, greater plasma and microsomal stability.
体外研究：
Balixafortide potently inhibits pERK / pAKT signaling in the lymphoma lines Namalwa (IC50Balixafortide 相关抗体:
Balixafortide (POL6326) is a potent, selective, well-tolerated peptidic CXCR4 antagonist with an IC50 < 10 nM. Balixafortide shows 1000-fold selective for CXCR4 than a large panel of receptors including CXCR7. Balixafortide blocks β-arrestin recruitment and calcium flux with IC50s < 10 nM. Balixafortide is also a potent hematopoietic stem and progenitor cell (HSPC) mobilizing agent. Anti-cancer effects.
体内研究：
Balixafortide is optimized for favorable mouse absorption, distribution, metabolism and excretion (ADME) properties with balanced plasma protein binding, greater plasma and microsomal stability.
体外研究：
Balixafortide potently inhibits pERK / pAKT signaling in the lymphoma lines Namalwa (IC50Balixafortide 相关抗体:
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