产品
编 号：F189457
分子式：C8H19Cl2N3O2
分子量：260.16
分子式：C8H19Cl2N3O2
分子量：260.16
产品类型
规格
价格
是否有货
结构图
CAS No: 159190-45-1
产品详情
生物活性：
L-NIL dihydrochloride is an inducible NO synthase inhibitor, with an IC50 of 3.3 μM for miNOS.
体内研究：
L-NIL (10 and 30?mg/kg, IP) prevents the inflammation, oxidative stress and autophagy induced by renal IR in mice.Animal Model:Adult male Balb/c (20-25 g).
Dosage:10 and 30?mg/kg.
Administration:Intraperitoneally at the end of CLP and at 6?h after sepsis induction.
Result:Led to a negligible increase in plasma NGAL compared to sham mice.Led to a significant decrease in both TLR4 and IL1β?protein contents and clusterin transcript.Showed an increase in NFAT5 mRNA levels, as compared with mice treated with vehicle.Promoted a decrease in AR protein expression, as compared with animals treated with vehicle.
体外研究：
L-NIL produces a concentration-dependent inhibition of both the mouse inducible NOS (miNOS) and the rat brain constitutive NOS (rcNOS) and is considerably more potent for miNOS. The IC50 values for L-NIL with miNOS and rcNOS are 3.3 and 92 pM, respectively, indicating that L-NIL is 28-fold more selective for miNOS. In addition, L-NIL has approximately 6-fold greater potency for miNOS than either L-NMA or L-NNA.
L-NIL dihydrochloride is an inducible NO synthase inhibitor, with an IC50 of 3.3 μM for miNOS.
体内研究：
L-NIL (10 and 30?mg/kg, IP) prevents the inflammation, oxidative stress and autophagy induced by renal IR in mice.Animal Model:Adult male Balb/c (20-25 g).
Dosage:10 and 30?mg/kg.
Administration:Intraperitoneally at the end of CLP and at 6?h after sepsis induction.
Result:Led to a negligible increase in plasma NGAL compared to sham mice.Led to a significant decrease in both TLR4 and IL1β?protein contents and clusterin transcript.Showed an increase in NFAT5 mRNA levels, as compared with mice treated with vehicle.Promoted a decrease in AR protein expression, as compared with animals treated with vehicle.
体外研究：
L-NIL produces a concentration-dependent inhibition of both the mouse inducible NOS (miNOS) and the rat brain constitutive NOS (rcNOS) and is considerably more potent for miNOS. The IC50 values for L-NIL with miNOS and rcNOS are 3.3 and 92 pM, respectively, indicating that L-NIL is 28-fold more selective for miNOS. In addition, L-NIL has approximately 6-fold greater potency for miNOS than either L-NMA or L-NNA.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备