产品
编 号：F021825
分子式：C17H23IN4O4
分子量：474.29
分子式：C17H23IN4O4
分子量：474.29
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CAS No: 1050670-85-3
产品详情
生物活性：
Ro-51 is a potent and selective dual P2X3/P2X2/3 antagonist, with IC50 of 2 nM and 5 nM for P2X3 and P2X2/3, respectively. Ro-51 can be used for the research for pain.
体内研究：
Ro-51 suffers rapid clearance, short half-lives, and high protein binding in rat.Animal Model:Rat
Dosage:2 mg/kg (Pharmacokinetic Analysis)
Administration:Oral administration
Result:AUC= 237 ng/h/mL, T 1/2 =1.52 h
体外研究：
Ro-51 has highly selective for P2X 3 and P2X 2/3 exhibiting no antagonistic activity at other P2X receptor family members tested (P2X 1 , P2X 2 , P2X 4 , P2X 5 , and P2X 7 ) at concentrations up to 10 μM.RO51 also shows a significant drop in potency on human P2X3 receptors (IC50 = 110.5 and 0.04 nM, respectively for human and rat P2X3).
Ro-51 is a potent and selective dual P2X3/P2X2/3 antagonist, with IC50 of 2 nM and 5 nM for P2X3 and P2X2/3, respectively. Ro-51 can be used for the research for pain.
体内研究：
Ro-51 suffers rapid clearance, short half-lives, and high protein binding in rat.Animal Model:Rat
Dosage:2 mg/kg (Pharmacokinetic Analysis)
Administration:Oral administration
Result:AUC= 237 ng/h/mL, T 1/2 =1.52 h
体外研究：
Ro-51 has highly selective for P2X 3 and P2X 2/3 exhibiting no antagonistic activity at other P2X receptor family members tested (P2X 1 , P2X 2 , P2X 4 , P2X 5 , and P2X 7 ) at concentrations up to 10 μM.RO51 also shows a significant drop in potency on human P2X3 receptors (IC50 = 110.5 and 0.04 nM, respectively for human and rat P2X3).
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