产品
编 号：F188166
分子式：C21H23N4O7PS2
分子量：538.53
分子式：C21H23N4O7PS2
分子量：538.53
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
50mg
询价
询价
结构图
CAS No: 1579965-12-0
产品详情
生物活性：
GSK2983559 free acid (compound 3) is an orally active and potent receptor interacting protein 2 (RIP2) kinase inhibitor. GSK2983559 free acid can block many proinflammatory cytokine responses in vivo and in human inflammatory bowel disease explant samples.
体内研究：
GSK2983559 (oral gavage; 3 and 10 mg/kg; once) inhibits effectively MDP-induced IL-6 in mouse.Animal Model:C57BL/6 mice (female) injected with MDP (100 μg)
Dosage:3 and 10 mg/kg
Administration:Oral gavage; 3 and 10 mg/kg; once
Result:Suppressed serum IL-6 levels in a dose-dependent manner.
体外研究：
GSK2983559 (1-1024 nM; 2 h) blocks MDP-induced IL-8 in THP-1 cells.
GSK2983559 free acid (compound 3) is an orally active and potent receptor interacting protein 2 (RIP2) kinase inhibitor. GSK2983559 free acid can block many proinflammatory cytokine responses in vivo and in human inflammatory bowel disease explant samples.
体内研究：
GSK2983559 (oral gavage; 3 and 10 mg/kg; once) inhibits effectively MDP-induced IL-6 in mouse.Animal Model:C57BL/6 mice (female) injected with MDP (100 μg)
Dosage:3 and 10 mg/kg
Administration:Oral gavage; 3 and 10 mg/kg; once
Result:Suppressed serum IL-6 levels in a dose-dependent manner.
体外研究：
GSK2983559 (1-1024 nM; 2 h) blocks MDP-induced IL-8 in THP-1 cells.
产品资料
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