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编 号：F188111
分子式：C20H27N
分子量：281.44
分子式：C20H27N
分子量：281.44
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CAS No: 15793-40-5
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生物活性：
Terodiline, an antispasmodic agent, blocks hERG current with the IC50 of 375 nM.?Terodiline has both anticholinergic and calcium antagonist properties, and effectively reduces abnormal bladder contractions caused by detrusor instability.?Terodiline can be used for the research of urinary incontinence.
体内研究：
Terodiline (80 mg/kg; S.C.) is equipotent in inhibiting intravesical bladder pressure and carbachol-induced salivary secretion (ID50= 24 and 35 mg/kg, respectively), and in increasing pupil diameter (ED50=59 mg/kg).Animal Model:Fmale or male Hartley guinea pigs (200-600 g)
Dosage:80 mg/kg
Administration:Administered S.C.
Result:Yielded an ID50 of 24±6 mg/kg. Higher doses were Iethal.
Terodiline, an antispasmodic agent, blocks hERG current with the IC50 of 375 nM.?Terodiline has both anticholinergic and calcium antagonist properties, and effectively reduces abnormal bladder contractions caused by detrusor instability.?Terodiline can be used for the research of urinary incontinence.
体内研究：
Terodiline (80 mg/kg; S.C.) is equipotent in inhibiting intravesical bladder pressure and carbachol-induced salivary secretion (ID50= 24 and 35 mg/kg, respectively), and in increasing pupil diameter (ED50=59 mg/kg).Animal Model:Fmale or male Hartley guinea pigs (200-600 g)
Dosage:80 mg/kg
Administration:Administered S.C.
Result:Yielded an ID50 of 24±6 mg/kg. Higher doses were Iethal.
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