产品
编 号：F187976
分子式：C36H49N5O8S
分子量：711.87
分子式：C36H49N5O8S
分子量：711.87
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
50mg
询价
询价
100mg
询价
询价
结构图
CAS No: 157810-81-6
产品详情
生物活性：
Indinavir sulfate (MK-639) is an orally active and selective HIV-1 protease inhibitor with a Ki of 0.54 nM for PR. Indinavir sulfate exhibits anticancer activity by inhibiting the activation of MMPs-2 hydrolysis, anti-angiogenesis and inducing apoptosis. Indinavir sulfate is also a SARS-CoV 3CLpro inhibitor.
体内研究：
Indinavir suLfate (70 mg/kg；ig；每天一次，持续 3 周) 在体内抑制肝癌细胞的生长。Animal Model:Nude mice(s.c. into Huh7 and SK-HEP-1 cells).
Dosage:70 mg/kg
Administration:Oral gavage; once a day for 3 weeks.
Result:Delaied the growth of s.c. implanted hepatocarcinoma xenografts in nude mice compared with placebo.
体外研究：
Indinavir suLfate (0-50 μM；18 h) 阻断 PBMC 细胞 G0/G1 期的淋巴细胞周期并损害淋巴增殖反应。Indinavir suLfate (40 μM-40 nM；5 天) 在体外抑制细胞侵袭并 (40 μM-40 nM; 48 h) 激活 Huh7 和 SK-HEP-1 肝癌细胞的 MMPs-2。
Indinavir sulfate (MK-639) is an orally active and selective HIV-1 protease inhibitor with a Ki of 0.54 nM for PR. Indinavir sulfate exhibits anticancer activity by inhibiting the activation of MMPs-2 hydrolysis, anti-angiogenesis and inducing apoptosis. Indinavir sulfate is also a SARS-CoV 3CLpro inhibitor.
体内研究：
Indinavir suLfate (70 mg/kg；ig；每天一次，持续 3 周) 在体内抑制肝癌细胞的生长。Animal Model:Nude mice(s.c. into Huh7 and SK-HEP-1 cells).
Dosage:70 mg/kg
Administration:Oral gavage; once a day for 3 weeks.
Result:Delaied the growth of s.c. implanted hepatocarcinoma xenografts in nude mice compared with placebo.
体外研究：
Indinavir suLfate (0-50 μM；18 h) 阻断 PBMC 细胞 G0/G1 期的淋巴细胞周期并损害淋巴增殖反应。Indinavir suLfate (40 μM-40 nM；5 天) 在体外抑制细胞侵袭并 (40 μM-40 nM; 48 h) 激活 Huh7 和 SK-HEP-1 肝癌细胞的 MMPs-2。
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