产品
编 号：F021687
分子式：C18H20N2O5
分子量：344.36
分子式：C18H20N2O5
分子量：344.36
产品类型
规格
价格
是否有货
100mg
询价
询价
结构图
CAS No: 1050-28-8
产品详情
生物活性：
H-Tyr-Tyr-OH (L-Tyrosyl-L-tyrosine) is an antihypertensive peptide. H-Tyr-Tyr-OH inhibits angiotensin I-converting enzyme (ACE) with an IC50 value of 0.028 mg/mL. H-Tyr-Tyr-OH can be used for the research of high blood pressure.
体内研究：
H-Tyr-Tyr-OH (12.5 mg/kg; intraarterial injection once) effects systolic blood pressure in vivo.H-Tyr-Tyr-OH (0-100 mg/kg; i.p. once) effects blood pressure of spontaneously hypertensive rats.Animal Model:Anesthetized male SpragueDawley rats
Dosage:12.5 mg/kg
Administration:Intraarterial injection; 12.5 mg/kg once
Result:Significantly elevated systolic blood pressure, with a peak increase of 5 min after administration.
Animal Model:Spontaneously hypertensive rats
Dosage:0, 50 and 100 mg/kg
Administration:Intraperitoneal injection; once
Result:Significantly reduced blood pressure of spontaneously hypertensive rats, even at a dose of 50 mg/kg.
体外研究：
H-Tyr-Tyr-OH shows inhibitory effect against ACE with an IC50 value of 0.028 mg/mL.
H-Tyr-Tyr-OH (L-Tyrosyl-L-tyrosine) is an antihypertensive peptide. H-Tyr-Tyr-OH inhibits angiotensin I-converting enzyme (ACE) with an IC50 value of 0.028 mg/mL. H-Tyr-Tyr-OH can be used for the research of high blood pressure.
体内研究：
H-Tyr-Tyr-OH (12.5 mg/kg; intraarterial injection once) effects systolic blood pressure in vivo.H-Tyr-Tyr-OH (0-100 mg/kg; i.p. once) effects blood pressure of spontaneously hypertensive rats.Animal Model:Anesthetized male SpragueDawley rats
Dosage:12.5 mg/kg
Administration:Intraarterial injection; 12.5 mg/kg once
Result:Significantly elevated systolic blood pressure, with a peak increase of 5 min after administration.
Animal Model:Spontaneously hypertensive rats
Dosage:0, 50 and 100 mg/kg
Administration:Intraperitoneal injection; once
Result:Significantly reduced blood pressure of spontaneously hypertensive rats, even at a dose of 50 mg/kg.
体外研究：
H-Tyr-Tyr-OH shows inhibitory effect against ACE with an IC50 value of 0.028 mg/mL.
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