产品
编 号：F187430
分子式：C25H48FO5P
分子量：478.62
分子式：C25H48FO5P
分子量：478.62
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CAS No: 1572051-31-0
产品详情
生物活性：
O-7460 is a potent and selective DAGLα inhibitor, with an IC50 of 0.69 μM. O-7460 shows selectivity over onoacylglycerol lipase (MAGL), human CB1 and CB2 cannabinoid receptors. O-7460 can decrease HFD-caused an up-regulation of 2-AG levels.
体内研究：
O-7460 (6-12 mg/kg; a single i.p.) induces a time- and dose-dependent decrease in high-fat diet (HFD) intake and counteracts the body weight increase of mice.O-7460 (12 mg/kg; i.p.) decreases the HFD-caused an up-regulation of 2-AG levels in the hypothalamus and liver of mice.Animal Model:Seven-week-old male C57BL/6N inbred mice were administrated high-fat diet (HFD) diet
Dosage:6, 12 mg/kg
Administration:A single i.p.
Result:Induced a time (30 min, 60 min and 14 h after O-7460 administration) and dose-dependent decrease in HFD intake.The highest dose significantly counteracted the body weight increase.
体外研究：
O-7460 (10 μM; 20 min) decreases the Ionomycin (3 μM)-induced formation of 2-AG in N18TG2 cells.
O-7460 is a potent and selective DAGLα inhibitor, with an IC50 of 0.69 μM. O-7460 shows selectivity over onoacylglycerol lipase (MAGL), human CB1 and CB2 cannabinoid receptors. O-7460 can decrease HFD-caused an up-regulation of 2-AG levels.
体内研究：
O-7460 (6-12 mg/kg; a single i.p.) induces a time- and dose-dependent decrease in high-fat diet (HFD) intake and counteracts the body weight increase of mice.O-7460 (12 mg/kg; i.p.) decreases the HFD-caused an up-regulation of 2-AG levels in the hypothalamus and liver of mice.Animal Model:Seven-week-old male C57BL/6N inbred mice were administrated high-fat diet (HFD) diet
Dosage:6, 12 mg/kg
Administration:A single i.p.
Result:Induced a time (30 min, 60 min and 14 h after O-7460 administration) and dose-dependent decrease in HFD intake.The highest dose significantly counteracted the body weight increase.
体外研究：
O-7460 (10 μM; 20 min) decreases the Ionomycin (3 μM)-induced formation of 2-AG in N18TG2 cells.
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