产品
编 号：F187367
分子式：C19H27NO6
分子量：365.42
分子式：C19H27NO6
分子量：365.42
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CAS No: 157148-06-6
产品详情
生物活性：
Harzianic acid, a tetramic acid derivative, with activity of antimicrobial, antibiofilm formation and biofilm disaggregation. Harzianic acid interferes with biofilm formation by limiting bacterial iron availability. Harzianic acid is also a selective inhibitor of Acetohydroxyacid synthase (AHAS), the first enzyme in the branched-chain amino acid biosynthetic pathway. Harzianic acid can used for herbicide and fungicide.
体外研究：
Harzianic acid 对 MRSP 和 MSSP 表现出较强的抑菌活性，MIC 值分别为 32 μg/mL 和 16 μg/mL 。Harzianic acid (8-128 μg/mL) 对 HaCaT 细胞毒性较低。Harzianic acid 作为一种竞争性抑制剂抑制真菌 ThAHAS, Ki 为 6.65 μM。Harzianic acid (0.1-100 μg/mL) 对病原真菌的生长有抑制作用。
Harzianic acid, a tetramic acid derivative, with activity of antimicrobial, antibiofilm formation and biofilm disaggregation. Harzianic acid interferes with biofilm formation by limiting bacterial iron availability. Harzianic acid is also a selective inhibitor of Acetohydroxyacid synthase (AHAS), the first enzyme in the branched-chain amino acid biosynthetic pathway. Harzianic acid can used for herbicide and fungicide.
体外研究：
Harzianic acid 对 MRSP 和 MSSP 表现出较强的抑菌活性，MIC 值分别为 32 μg/mL 和 16 μg/mL 。Harzianic acid (8-128 μg/mL) 对 HaCaT 细胞毒性较低。Harzianic acid 作为一种竞争性抑制剂抑制真菌 ThAHAS, Ki 为 6.65 μM。Harzianic acid (0.1-100 μg/mL) 对病原真菌的生长有抑制作用。
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