产品
编 号：F021529
分子式：C68H48O44
分子量：1569.08
分子式：C68H48O44
分子量：1569.08
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 104987-36-2
产品详情
生物活性：
Oenothein B is a dimeric macrocyclic ellagitannin and has widely pharmacological activities, including antioxidant, anti-inflammatory, antifungal, anti-HCV, and antitumor properties. Oenothein B is a potent and specific inhibitor of poly(ADP-ribose) glycohydrolase.
体内研究：
Oenothein B (100-300 mg/kg; p.o.) has the ability to reduce neuroinflammation in the brain during systemic inflammation in ICR mice.
体外研究：
Oenothein B (15-45 μM; 12-72 hours) has a dose- and time-dependent inhibition rate effect on A549 cells in the range of 12hours, 24hours, 36hours, 48hours, 60hours and 72 hours of exposure.Oenothein B (15-45 μM; 24 hours) effectively inhibits the proliferation of A549 cells by inducing apoptosis and arresting cells at G1 stage. Oenothein B (15-45 μM; 24 hours) not only increases the level of intracellular reactive oxygen species (ROS), but also induces the upregulation of intracellular apoptotic triggers (cleavage caspase-3, PARP, cytochrome c level in the cytosol, Bax).A549 cells15 μM, 30 μM and 45 μM24hoursArrested cells in the G1 phase.A549 cells15 μM, 30 μM and 45 μM24hoursBAX, p53, cytochrome c (cytoplasm) and PARP were unregulated significantly; Anti-apoptotic Bcl-2 was decreased significantly in a concentration-dependent manner.
Oenothein B is a dimeric macrocyclic ellagitannin and has widely pharmacological activities, including antioxidant, anti-inflammatory, antifungal, anti-HCV, and antitumor properties. Oenothein B is a potent and specific inhibitor of poly(ADP-ribose) glycohydrolase.
体内研究：
Oenothein B (100-300 mg/kg; p.o.) has the ability to reduce neuroinflammation in the brain during systemic inflammation in ICR mice.
体外研究：
Oenothein B (15-45 μM; 12-72 hours) has a dose- and time-dependent inhibition rate effect on A549 cells in the range of 12hours, 24hours, 36hours, 48hours, 60hours and 72 hours of exposure.Oenothein B (15-45 μM; 24 hours) effectively inhibits the proliferation of A549 cells by inducing apoptosis and arresting cells at G1 stage. Oenothein B (15-45 μM; 24 hours) not only increases the level of intracellular reactive oxygen species (ROS), but also induces the upregulation of intracellular apoptotic triggers (cleavage caspase-3, PARP, cytochrome c level in the cytosol, Bax).A549 cells15 μM, 30 μM and 45 μM24hoursArrested cells in the G1 phase.A549 cells15 μM, 30 μM and 45 μM24hoursBAX, p53, cytochrome c (cytoplasm) and PARP were unregulated significantly; Anti-apoptotic Bcl-2 was decreased significantly in a concentration-dependent manner.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备