产品
编 号：F187117
分子式：C11H9N3O2
分子量：215.21
分子式：C11H9N3O2
分子量：215.21
产品类型
规格
价格
是否有货
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 15687-37-3
产品详情
生物活性：
Naftazone is a naphthoquinone derivative, it can be used for the research of venous insufciency. Naftazone protects blood vessels, increases venous tonicity and capillary resistance, and improves lymphatic and venous circulation.
体内研究：
Naftazone (10 and 100 mg/kg; p.o. once per day for 15 days) affects glutamate content in cerebro spinal fluid.Naftazone (50 mg/kg; i.p. once per day for 5 days) affects platelet function in rats.Animal Model:Male rats
Dosage:10 and 100 mg/kg
Administration:Oral gavage; 10 and 100 mg/kg once per day; for 15 days
Result:Significantly reduced glutamate content in cerebro spinal fluid of rats.
Animal Model:Wistar rats
Dosage:50 mg/kg
Administration:Intraperitoneal injection ; 50 mg/kg once daily for 5 days
Result:Reduced the height of platelet aggregation induced by ADP, significantly increased the platelet disaggregation induced by collagen and reduced fibrinogen binding to 2.5 or 5 μM ADP-stimulated platelet.
体外研究：
Naftazone (0.5-50 μM; 1 h) reduces glutamate release from mouse cerebellum synaptosomes.
Naftazone is a naphthoquinone derivative, it can be used for the research of venous insufciency. Naftazone protects blood vessels, increases venous tonicity and capillary resistance, and improves lymphatic and venous circulation.
体内研究：
Naftazone (10 and 100 mg/kg; p.o. once per day for 15 days) affects glutamate content in cerebro spinal fluid.Naftazone (50 mg/kg; i.p. once per day for 5 days) affects platelet function in rats.Animal Model:Male rats
Dosage:10 and 100 mg/kg
Administration:Oral gavage; 10 and 100 mg/kg once per day; for 15 days
Result:Significantly reduced glutamate content in cerebro spinal fluid of rats.
Animal Model:Wistar rats
Dosage:50 mg/kg
Administration:Intraperitoneal injection ; 50 mg/kg once daily for 5 days
Result:Reduced the height of platelet aggregation induced by ADP, significantly increased the platelet disaggregation induced by collagen and reduced fibrinogen binding to 2.5 or 5 μM ADP-stimulated platelet.
体外研究：
Naftazone (0.5-50 μM; 1 h) reduces glutamate release from mouse cerebellum synaptosomes.
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