产品
编 号：F186123
分子式：C19H18O5
分子量：326.34
分子式：C19H18O5
分子量：326.34
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CAS No: 156398-61-7
产品详情
生物活性：
Ailanthoidol is a natural occurring neolignan, with anti-inflammatory and antitumor activities. Ailanthoidol has chemopreventive activity against tumor promotion.
体内研究：
Ailanthoidol (0.1-10 mg/kg; i.g.; 24 hours and 1 hours before LPS was injected, for 5 days) protects BALB/c mice from LPS (25mg/kg)-induced endotoxin shock, possibly through inhibition of the production of inflammatory cytokines and NO.Animal Model:Eight-week-old male BALB/c mice
Dosage:0.1 mg/kg, 1 mg/kg, 10 mg/kg, 20 mg/kg
Administration:Oral gavage, 24 hours and 1 hours before LPS was injected, for 5 days
Result:Significantly improved the mortality of these mice in a concentration-dependent manner and no mice were killed in the 20mg/kg group.
体外研究：
Ailanthoidol (20 μM; 24-72 hours) showed no cytotoxicity toward RAW264.7 macrophages. Ailanthoidol (1.25-20 μM; 24 hours) suppresses the generation of nitric oxide (NO) and prostaglandin E2 , aswell as theexpression of inducible NO synthase (iNOS) and cyclooxygenase (COX)-2 induced by lipopolysaccharide (LPS) in RAW264.7 cells.Ailanthoidol (1.25-20 μM; 24 hours) inhibits the production of inflammatory cytokines induced by LPS in RAW264.7 cells, including interleukin (IL)-1b and IL-6.Ailanthoidol suppresses NF-kB activation by blocking Ik-Ba degradation.
Ailanthoidol is a natural occurring neolignan, with anti-inflammatory and antitumor activities. Ailanthoidol has chemopreventive activity against tumor promotion.
体内研究：
Ailanthoidol (0.1-10 mg/kg; i.g.; 24 hours and 1 hours before LPS was injected, for 5 days) protects BALB/c mice from LPS (25mg/kg)-induced endotoxin shock, possibly through inhibition of the production of inflammatory cytokines and NO.Animal Model:Eight-week-old male BALB/c mice
Dosage:0.1 mg/kg, 1 mg/kg, 10 mg/kg, 20 mg/kg
Administration:Oral gavage, 24 hours and 1 hours before LPS was injected, for 5 days
Result:Significantly improved the mortality of these mice in a concentration-dependent manner and no mice were killed in the 20mg/kg group.
体外研究：
Ailanthoidol (20 μM; 24-72 hours) showed no cytotoxicity toward RAW264.7 macrophages. Ailanthoidol (1.25-20 μM; 24 hours) suppresses the generation of nitric oxide (NO) and prostaglandin E2 , aswell as theexpression of inducible NO synthase (iNOS) and cyclooxygenase (COX)-2 induced by lipopolysaccharide (LPS) in RAW264.7 cells.Ailanthoidol (1.25-20 μM; 24 hours) inhibits the production of inflammatory cytokines induced by LPS in RAW264.7 cells, including interleukin (IL)-1b and IL-6.Ailanthoidol suppresses NF-kB activation by blocking Ik-Ba degradation.
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