产品
编 号：F185908
分子式：C19H22Cl2N2O2
分子量：381.3
分子式：C19H22Cl2N2O2
分子量：381.3
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
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1mg
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5mg
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10mg
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50mg
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100mg
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结构图
CAS No: 156223-05-1
产品详情
生物活性：
GTS-21 dihydrochloride is a selective alpha7 nicotinic acetylcholine receptor (α7-nAChR) agonist with anti?inflammatory and cognition?enhancing activities. GTS-21 dihydrochloride is also a α4β2 (Ki=20 nM for humanα4β2) and 5-HT3A receptor (IC50=3.1 μM) antagonist.
体内研究：
GTS 21 (4 mg/kg; i.p.; 1, 3, 7, 14 and 21 days) reduces radiation induced histological signs of pulmonary injury.Animal Model:C57BL6 mice were irradiated with 12 Gy to induce a mouse model of Radiation induced lung injury (RILI)
Dosage:4 mg/kg
Administration:I.p.; 1, 3, 7, 14 and 21 days
Result:Reduces lung inflammatory infiltrate and fibrosis in radiation treated mice.
体外研究：
GTS-21 bound to human α4β2 nAChR (Ki=20 nM) 100-fold more potently than to humanα7-nAChR, and is 18- and 2-fold less potent than (-)-nicotine at human α4β2 and a7 nAChR, respectively.
GTS-21 dihydrochloride is a selective alpha7 nicotinic acetylcholine receptor (α7-nAChR) agonist with anti?inflammatory and cognition?enhancing activities. GTS-21 dihydrochloride is also a α4β2 (Ki=20 nM for humanα4β2) and 5-HT3A receptor (IC50=3.1 μM) antagonist.
体内研究：
GTS 21 (4 mg/kg; i.p.; 1, 3, 7, 14 and 21 days) reduces radiation induced histological signs of pulmonary injury.Animal Model:C57BL6 mice were irradiated with 12 Gy to induce a mouse model of Radiation induced lung injury (RILI)
Dosage:4 mg/kg
Administration:I.p.; 1, 3, 7, 14 and 21 days
Result:Reduces lung inflammatory infiltrate and fibrosis in radiation treated mice.
体外研究：
GTS-21 bound to human α4β2 nAChR (Ki=20 nM) 100-fold more potently than to humanα7-nAChR, and is 18- and 2-fold less potent than (-)-nicotine at human α4β2 and a7 nAChR, respectively.
产品资料
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