产品
编 号：F185148
分子式：C19H23ClN2O3S
分子量：394.92
分子式：C19H23ClN2O3S
分子量：394.92
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
结构图
CAS No: 1557240-80-8
产品详情
生物活性：
BNC375 is a potent, selective, and orally available type I positive allosteric modulator of α7 nAChRs with an EC50 of 1.9 μM. BNC375 exhibits good CNS-agent like properties and clinical candidate potential. .
体内研究：
BNC375 (0.003-10.0 mg/kg, administered orally) exhibits the MED of 0.03 mg/kg, and achieves full reversal of the Scopolamine-induced impairment at 1.0 mg/kg in mouse T-maze model. BNC375 exhibits the plasm half-life (t1/2) of 1.2 h.
体外研究：
BNC375 significantly potentiates the acetylcholine signal without changing the rapid receptor desensitization.
BNC375 is a potent, selective, and orally available type I positive allosteric modulator of α7 nAChRs with an EC50 of 1.9 μM. BNC375 exhibits good CNS-agent like properties and clinical candidate potential. .
体内研究：
BNC375 (0.003-10.0 mg/kg, administered orally) exhibits the MED of 0.03 mg/kg, and achieves full reversal of the Scopolamine-induced impairment at 1.0 mg/kg in mouse T-maze model. BNC375 exhibits the plasm half-life (t1/2) of 1.2 h.
体外研究：
BNC375 significantly potentiates the acetylcholine signal without changing the rapid receptor desensitization.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备