产品
编 号：F184816
分子式：C22H24Cl3N3OS
分子量：484.87
分子式：C22H24Cl3N3OS
分子量：484.87
产品类型
规格
价格
是否有货
5mg
询价
询价
结构图
CAS No: 155512-52-0
产品详情
生物活性：
DIPPA (hydrochloride) is an irreversible, long-lasting, selective and high affinity κ-opioid receptor antagonist. DIPPA (hydrochloride) can be used for the research of anxiety and antidepressant.
体内研究：
DIPPA (2.5 and 5 mg/kg; s.c.) hydrochloride decreases the latency to feed in Wistar Kyoto rats, but treatment did not alter approach latencies in SD rats. DIPPA (1 and 5 mg/kg; s.c.) hydrochloride high dose increases immobility in SD rats compared to the saline-treated strain control group. DIPPA (5 mg/kg) hydrochloride decreases consumption in SD rats compared to the 5 mg/kg group of Wistar Kyoto rats. DIPPA hydrochloride significantly decreases burying time in both strains. DIPPA (5 mg/kg) hydrochloride decreases burying in both strains compared to the within strain control groups. DIPPA hydrochloride tends to decrease consumption in SD rats in the home cage but significantly increases feeding in the novel cage where potential anxiolytic-like effects of DIPPA hydrochloride may oppose the hypophagic effects of the compound.Animal Model:Wistar Kyoto rats and SD rats (250–300 g)
Dosage:2.5 and 5 mg/kg
Administration:S.c.
Result:Decreased the latency to feed in Wistar Kyoto rats, but treatment did not alter approach latencies in SD rats.
Animal Model:Wistar Kyoto rats and SD rats (250–300 g)
Dosage:1 and 5 mg/kg
Administration:S.c.
Result:High dose increased immobility in SD rats compared to the saline-treated strain control group.
DIPPA (hydrochloride) is an irreversible, long-lasting, selective and high affinity κ-opioid receptor antagonist. DIPPA (hydrochloride) can be used for the research of anxiety and antidepressant.
体内研究：
DIPPA (2.5 and 5 mg/kg; s.c.) hydrochloride decreases the latency to feed in Wistar Kyoto rats, but treatment did not alter approach latencies in SD rats. DIPPA (1 and 5 mg/kg; s.c.) hydrochloride high dose increases immobility in SD rats compared to the saline-treated strain control group. DIPPA (5 mg/kg) hydrochloride decreases consumption in SD rats compared to the 5 mg/kg group of Wistar Kyoto rats. DIPPA hydrochloride significantly decreases burying time in both strains. DIPPA (5 mg/kg) hydrochloride decreases burying in both strains compared to the within strain control groups. DIPPA hydrochloride tends to decrease consumption in SD rats in the home cage but significantly increases feeding in the novel cage where potential anxiolytic-like effects of DIPPA hydrochloride may oppose the hypophagic effects of the compound.Animal Model:Wistar Kyoto rats and SD rats (250–300 g)
Dosage:2.5 and 5 mg/kg
Administration:S.c.
Result:Decreased the latency to feed in Wistar Kyoto rats, but treatment did not alter approach latencies in SD rats.
Animal Model:Wistar Kyoto rats and SD rats (250–300 g)
Dosage:1 and 5 mg/kg
Administration:S.c.
Result:High dose increased immobility in SD rats compared to the saline-treated strain control group.
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