产品
编 号:F183952
分子式:C205H340N60O53
分子量:4493.26
产品类型
结构图
CAS No: 154947-66-7
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产品详情
生物活性:
LL-37, human is a 37-residue, amphipathic, cathelicidin-derived antimicrobial peptide, which exhibits a broad spectrum of antimicrobial activity. LL-37, human could help protect the cornea from infection and modulates wound healing.
体内研究:
LL-37, human (0.4-2.0 mg/kg; intratracheal injection once) ameliorates MRSA-induced pneumonia of mice.Animal Model:6-8 week-old C57BL/6 mice with MRSA-induced pneumonia
Dosage:0.4, 0.8, 1.2, 1.6 and 2.0 mg/kg
Administration:Intratracheal injection; 0.4-2.0 mg/kg once
Result:Decreased IL-6 and TNF-α release to attenuated MRSA-induced pneumonia of testing mice.
体外研究:
LL-37, human (1-20 μg/mL; 24 h) affects HCECs migration.LL-37, human (0.0001-5 μg/mL;6-24 h) affects cytokine secretion in HCECs.LL-37, human (1-100 μg/mL; 24 h) shows dose-dependently cytotoxic to HCECs at concentrations over 10 μg /mL.