产品
编 号:F183841
分子式:C12H19ClN4O7P2S
分子量:460.77
产品类型
结构图
CAS No: 154-87-0
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产品详情
生物活性:
Thiamine pyrophosphate is the coenzyme form of Vitamin B1, and is a required intermediate in the pyruvate dehydrogenase complex and the ketoglutarate dehydrogenase complex. Thiamine pyrophosphate is necessary for oxidative phosphorylation and the pentose phosphate pathway by acting as a cofactor for α-ketoacid dehydrogenases.
体内研究:
Thiamine pyrophosphate (25 mg/kg,腹腔注射) 抑制大鼠卵巢组织缺血再灌注诱导的氧化损伤。Thiamine pyrophosphate (20 mg/kg,腹腔注射,每天一次,持续 14 天) 可预防顺铂 (HY-17394) 诱导的大鼠心脏毒性以及相关的氧化应激和心脏损伤。