产品
编 号：F183120
分子式：C12H30Cl4N4O6
分子量：468.2
分子式：C12H30Cl4N4O6
分子量：468.2
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CAS No: 15446-43-2
产品详情
生物活性：
Neamine tetrahydrochloride, a degradation product of Neomycin, is a broad-spectrum aminoglycoside antibiotic. Neamine tetrahydrochloride is an anti-angiogenesis agent targeting angiogenin. Neamine tetrahydrochloride has potent antibacterial, antitumor and neuroprotective activities.
体内研究：
Neamine (30-60 mg/kg; subcutaneous injection; daily; for 14 days; male Balb/c nude mice) has anti-tumor effects on AsPC-1 xenograft models. Neamine reduces the expression levels of ANG, Ki-67 and CD31 in tumor xenografts.Animal Model:Male Balb/c nude mice (4 weeks old) injected with AsPC-1 cells
Dosage:30 mg/kg, 60 mg/kg
Administration:Subcutaneous injection; daily; for 14 days
Result:Had anti-tumor effects on AsPC-1 xenograft models.
体外研究：
Neamine (0.625-25 μM; 48 hours; AsPC-1 cells) treatment inhibits ANG-mediated AsPC-1 cell proliferation in a dose-dependent manner in the range of 0.625-25 μM.Neamine (100 μM) also blocks the nuclear translocation of ANG effectively.
Neamine tetrahydrochloride, a degradation product of Neomycin, is a broad-spectrum aminoglycoside antibiotic. Neamine tetrahydrochloride is an anti-angiogenesis agent targeting angiogenin. Neamine tetrahydrochloride has potent antibacterial, antitumor and neuroprotective activities.
体内研究：
Neamine (30-60 mg/kg; subcutaneous injection; daily; for 14 days; male Balb/c nude mice) has anti-tumor effects on AsPC-1 xenograft models. Neamine reduces the expression levels of ANG, Ki-67 and CD31 in tumor xenografts.Animal Model:Male Balb/c nude mice (4 weeks old) injected with AsPC-1 cells
Dosage:30 mg/kg, 60 mg/kg
Administration:Subcutaneous injection; daily; for 14 days
Result:Had anti-tumor effects on AsPC-1 xenograft models.
体外研究：
Neamine (0.625-25 μM; 48 hours; AsPC-1 cells) treatment inhibits ANG-mediated AsPC-1 cell proliferation in a dose-dependent manner in the range of 0.625-25 μM.Neamine (100 μM) also blocks the nuclear translocation of ANG effectively.
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