产品
编 号：F183070
分子式：C34H32N4O4Zn
分子量：626.02
分子式：C34H32N4O4Zn
分子量：626.02
产品类型
规格
价格
是否有货
1mg
520
In-stock
5mg
1360
In-stock
10mg
2200
In-stock
25mg
4360
In-stock
结构图
CAS No: 15442-64-5
产品详情
生物活性：
Zinc Protoporphyrin (Zn(II)-protoporphyrin IX) is an orally active and competitive heme oxygenase-1 (HO-1) inhibitor and markedly attenuates the protective effects of Phloroglucinol (PG) against H2O2. Zinc Protoporphyrin is used as a screening marker of iron deficiency in individual pregnant women and children, but also to assess population iron status in combination with haemoglobin concentration. Zinc Protoporphyrin has anti-cancer activity.
体内研究：
原卟啉锌 (12.5、25、50 mg/kg 腹腔注射；12.5、50 mg/kg 口服；从第 7 天到第 19 天) 发挥剂量依赖性抗肿瘤作用，表现为延缓肿瘤生长。Animal Model:BALB/c mice inoculated with C-26 cells
Dosage:12.5, 25, 50 mg/kg for i.p.; 12.5, 50 mg/kg for p.o.
Administration:IP or PO; from day 7 to 19
Result:Exerted dose-dependent antitumor effects manifested by the retardation of tumor growth.
体外研究：
Zinc Protoporphyrin (Zn (II)-protoporphyrin IX；5 μM；72 hours) 导致晚期凋亡和坏死细胞的比例从对照组的 10.9% 增加到 72 小时后的 30.4%。Zinc Protoporphyrin (1.25-40 μM；48 或 72 小时) 对肿瘤细胞产生抑囊/细胞毒性作用。Zinc Protoporphyrin (2.5、5 μM；48 或 72 小时) 导致细胞周期 G1 期细胞的剂量和时间依赖性减少。Zinc Protoporphyrin (1.25-40 μM；48 小时) 导致裂解 (活性) caspase-3 的积累。
Zinc Protoporphyrin (Zn(II)-protoporphyrin IX) is an orally active and competitive heme oxygenase-1 (HO-1) inhibitor and markedly attenuates the protective effects of Phloroglucinol (PG) against H2O2. Zinc Protoporphyrin is used as a screening marker of iron deficiency in individual pregnant women and children, but also to assess population iron status in combination with haemoglobin concentration. Zinc Protoporphyrin has anti-cancer activity.
体内研究：
原卟啉锌 (12.5、25、50 mg/kg 腹腔注射；12.5、50 mg/kg 口服；从第 7 天到第 19 天) 发挥剂量依赖性抗肿瘤作用，表现为延缓肿瘤生长。Animal Model:BALB/c mice inoculated with C-26 cells
Dosage:12.5, 25, 50 mg/kg for i.p.; 12.5, 50 mg/kg for p.o.
Administration:IP or PO; from day 7 to 19
Result:Exerted dose-dependent antitumor effects manifested by the retardation of tumor growth.
体外研究：
Zinc Protoporphyrin (Zn (II)-protoporphyrin IX；5 μM；72 hours) 导致晚期凋亡和坏死细胞的比例从对照组的 10.9% 增加到 72 小时后的 30.4%。Zinc Protoporphyrin (1.25-40 μM；48 或 72 小时) 对肿瘤细胞产生抑囊/细胞毒性作用。Zinc Protoporphyrin (2.5、5 μM；48 或 72 小时) 导致细胞周期 G1 期细胞的剂量和时间依赖性减少。Zinc Protoporphyrin (1.25-40 μM；48 小时) 导致裂解 (活性) caspase-3 的积累。
产品资料
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