产品
编 号:F182793
分子式:C14H15N3O
分子量:241.29
产品类型
结构图
CAS No: 154235-83-3
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生物活性:
CX516 (BDP 12) is an ampakine and acts as an AMPA receptor positive allosteric modulator for the research of Alzheimer's disease, schizophrenia and mild cognitive impairment (MCI).
体内研究:
The specific extradimensional deficits produced by sub-chronic or early postnatal postnatal phencyclidine treatment were significantly attenuated by CX516 (10, and 20 mg/kg, s.c.).Animal Model:Male Lister Hooded rats (56-63 postnatal day)
Dosage:5, 10, 20, and 40 mg/kg
Administration:Subcutaneously
Result:Two doses (10 and 20 mg/kg) were highly significant in improving the extradimensional shift deficit induced by either treatment regimes. Two doses (5 and 40 mg/kg) was ineffective at reversing the extradimensional impairment induced by the sub-chronic postnatal phencyclidine treatment regime.