产品
编 号:F020561
分子式:C25H31N3O3
分子量:421.53
产品类型
结构图
CAS No: 1048668-70-7
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产品详情
生物活性:
AZD8329 is a potent 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor with an IC50 of 9 nM for human 11β-HSD1, displays excellent selectivity versus 11β-HSD2, 17β-HSD1 and 17β-HSD3.
体外研究:
AZD8329 shows IC50s of 0.009, 0.0086, 0.008, 0.024, 0.002 and 6.1 μM for human enzyme, rat enzyme, dog enzyme, cyno enzyme, human adipocyte and mouse enzyme, respectively.