产品
编 号：F182746
分子式：C26H36N6O6
分子量：528.6
分子式：C26H36N6O6
分子量：528.6
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
结构图
CAS No: 1542132-88-6
产品详情
生物活性：
ZED-1227 is a specific and orally active transglutaminase 2 (TG2) inhibitor, with an IC50 of 45 nM. ZED-1227 can block inflammation-induced TG2 expression and activity. ZED-1227 can be used for the research of celiac disease (CeD).
体内研究：
ZED-1227 reduces the activity of intestinal TG2 induced by Polyinosinic:Polycytidylic acid (40 mg/kg) to normal control levels and subdues intestinal inflammation in mice.?ZED-1227 (5 mg/kg; i.g.) is able to inhibit TG2 in the small intestinal mucosa.Animal Model:BALB/c mice
Dosage:5 mg/kg
Administration:Oral gavage
Result:Inhibited TG2 in vivo in the small intestinal mucosa.
体外研究：
ZED-1227 (0.1 μΜ-1 μΜ; 24 hours) has no effect on metabolic activity and proliferation in Huh7 cells and CaCo2 cells,? that suggests ZED-1227 has no cytotoxic activity.?ZED-1227 (0.002-0.2 mg/mL; 30 minutes) inhibits TG2 in the small intestinal mucosa in vitro.
ZED-1227 is a specific and orally active transglutaminase 2 (TG2) inhibitor, with an IC50 of 45 nM. ZED-1227 can block inflammation-induced TG2 expression and activity. ZED-1227 can be used for the research of celiac disease (CeD).
体内研究：
ZED-1227 reduces the activity of intestinal TG2 induced by Polyinosinic:Polycytidylic acid (40 mg/kg) to normal control levels and subdues intestinal inflammation in mice.?ZED-1227 (5 mg/kg; i.g.) is able to inhibit TG2 in the small intestinal mucosa.Animal Model:BALB/c mice
Dosage:5 mg/kg
Administration:Oral gavage
Result:Inhibited TG2 in vivo in the small intestinal mucosa.
体外研究：
ZED-1227 (0.1 μΜ-1 μΜ; 24 hours) has no effect on metabolic activity and proliferation in Huh7 cells and CaCo2 cells,? that suggests ZED-1227 has no cytotoxic activity.?ZED-1227 (0.002-0.2 mg/mL; 30 minutes) inhibits TG2 in the small intestinal mucosa in vitro.
产品资料
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