产品
编 号：F182460
分子式：C15H29N3O5
分子量：331.41
分子式：C15H29N3O5
分子量：331.41
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
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1mg
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5mg
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10mg
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50mg
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结构图
CAS No: 154039-60-8
产品详情
生物活性：
Marimastat (BB2516) is a broad spectrum and orally bioavailable inhibitor of MMPs, with potent activity against MMP-9 (IC50=3 nM), MMP-1 (IC50=5 nM), MMP-2 (IC50=6 nM), MMP-14 (IC50=9 nM) and MMP-7 (IC50=13 nM), used in the treatment of cancer. Marimastat (BB2516) is an angiogenesis and metastasis inhibitor, which limits the growth and production of blood vessels. As an antimetatstatic agent it prevents malignant cells from breaching the basement membranes.
体内研究：
与单独接受放化疗的动物相比，接受放化疗 + Marimastat (BB2516) (8.7 mg/kg) 的动物具有统计学上显著的生长延迟。Marimastat (BB2516) 可与化疗和放疗联合使用以抑制肿瘤生长。
体外研究：
Marimastat (BB2516) (1 μM) 可抑制血管生长，并选择性影响血管生成。
Marimastat (BB2516) is a broad spectrum and orally bioavailable inhibitor of MMPs, with potent activity against MMP-9 (IC50=3 nM), MMP-1 (IC50=5 nM), MMP-2 (IC50=6 nM), MMP-14 (IC50=9 nM) and MMP-7 (IC50=13 nM), used in the treatment of cancer. Marimastat (BB2516) is an angiogenesis and metastasis inhibitor, which limits the growth and production of blood vessels. As an antimetatstatic agent it prevents malignant cells from breaching the basement membranes.
体内研究：
与单独接受放化疗的动物相比，接受放化疗 + Marimastat (BB2516) (8.7 mg/kg) 的动物具有统计学上显著的生长延迟。Marimastat (BB2516) 可与化疗和放疗联合使用以抑制肿瘤生长。
体外研究：
Marimastat (BB2516) (1 μM) 可抑制血管生长，并选择性影响血管生成。
产品资料
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