产品
编 号：F182169
分子式：C23H29N3O2
分子量：379.5
分子式：C23H29N3O2
分子量：379.5
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 153-87-7
产品详情
生物活性：
Oxypertine is a neuroprotective agent. Oxypertine can be used in the research of neurological conditions, such as anxiety and schizophrenia.
体内研究：
Oxypertine (10 and 35 mg/kg, i.p.) causes an obvious dose-related depletion in the levels of norepinephrine (NE), dopamine (DA) and 5-hydroxytryptamine (5-HT) in various discrete regions of the rat brain.Oxypertine (0.625-20 mg/kg, i.p.) inhibits stereotyped behaviour induced by both amphetamine and apomorphine in rats.Animal Model:Mice with chronic restraint stress
Dosage:10, 35 mg/kg
Administration:Intraperitoneal injection (i.p.)
Result:Increased the level of homovanillic acid in three discrete regions, i.e., the cortex, striatum and mid-brain. Inhibited Apomorphine-induced stereotypy.
Animal Model:Mice with stereotyped behaviour induced by amphetamine (5.0 mg/kg i.p.) and apomorphine (1.0 mg/kg, s.c.)
Dosage:0.625-20 mg/kg
Administration:Intraperitoneal injection (i.p.)
Result:Reduced the content of dopamine in the striatum but increased the concentrations of homovanillic acid (HVA) and 3,4-dihydroxyphenylacetic acid (DOPAC).
体外研究：
Oxypertine (0.44 nM-26 μM, 15 min) antagonizes dopamine and 5-HT induced contractions of the rat isolated vas deferens.Oxypertine (8.8 nM, 15 min) reduces the contractions evoked by transmural stimulation of the vas deferens.
Oxypertine is a neuroprotective agent. Oxypertine can be used in the research of neurological conditions, such as anxiety and schizophrenia.
体内研究：
Oxypertine (10 and 35 mg/kg, i.p.) causes an obvious dose-related depletion in the levels of norepinephrine (NE), dopamine (DA) and 5-hydroxytryptamine (5-HT) in various discrete regions of the rat brain.Oxypertine (0.625-20 mg/kg, i.p.) inhibits stereotyped behaviour induced by both amphetamine and apomorphine in rats.Animal Model:Mice with chronic restraint stress
Dosage:10, 35 mg/kg
Administration:Intraperitoneal injection (i.p.)
Result:Increased the level of homovanillic acid in three discrete regions, i.e., the cortex, striatum and mid-brain. Inhibited Apomorphine-induced stereotypy.
Animal Model:Mice with stereotyped behaviour induced by amphetamine (5.0 mg/kg i.p.) and apomorphine (1.0 mg/kg, s.c.)
Dosage:0.625-20 mg/kg
Administration:Intraperitoneal injection (i.p.)
Result:Reduced the content of dopamine in the striatum but increased the concentrations of homovanillic acid (HVA) and 3,4-dihydroxyphenylacetic acid (DOPAC).
体外研究：
Oxypertine (0.44 nM-26 μM, 15 min) antagonizes dopamine and 5-HT induced contractions of the rat isolated vas deferens.Oxypertine (8.8 nM, 15 min) reduces the contractions evoked by transmural stimulation of the vas deferens.
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