产品
编 号：F181951
分子式：C22H24N3NaO7S
分子量：497.5
分子式：C22H24N3NaO7S
分子量：497.5
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
50mg
询价
询价
100mg
询价
询价
结构图
CAS No: 153773-82-1
产品详情
生物活性：
Ertapenem sodium (L-749345) is a broad spectrum and long acting β-lactam antibiotic. Ertapenem sodium has a broad-spectrum anti-anaerobic activity against a variety of anaerobes with a mode MIC of 0.12 μg/mL. Ertapenem sodium can be used for the research of severe infections caused by bacteria in the skin, lungs, stomach, pelvis, and urinary tract.
体内研究：
Ertapenem sodium (Subcutaneous injection, 0-10 mg/kg, 0-120 h after infection, S. aureus thigh tissue infection model) shows > 3 log10 CFU reduction of organism at 10 mg/kg, and maintains the activity with 3.3 and 4.4 log10 CFU eliminated at 2 mg/kg.Ertapenem sodium (Subcutaneous injection, 4h after infection, systemic infection model) is active against all gram-positive organisms, and is also active against gram-negative organisms tested with ED50s of3 log10 CFU reduction of organism compared to non-antibiotic-treated controls at 10 mg/kg.Maintained the activity with 3.3 and 4.4 log10 CFU eliminated at 2 mg/kg.
Animal Model:Systemic infection model (DBA/2 female mice, viral antibody-free CD-1 female mice)
Dosage:0-3 mg/kg approximately
Administration:Subcutaneous injection (0.5 mL, begin immediately and 4 h after infection)
Result:Showed activity against all gram-positive organisms, and also ram-negative organisms tested with ED50s of <0.25 mg/kg/dose.
Animal Model:CD-1 mice, rats
Dosage:10 mg/kg approximately
Administration:Intraperitoneal injection (pharmacokinetic assay)
Result:Exhibited an AUC0-∞ ranging from 1.8-21.82 μg?hr/mL in tissue in mice following a 10-mg/kg i.p. dose.Exhibited slow clearance rate with a t1/2β of 3.2 h, Clp of 0.47 mL/min/kg, AUC0-8 of 284.15 μg?hr/mL.
体外研究：
Ertapenem sodium (0-100 μg/mL approximately, 48 h) is active against 99.1% of all anaerobes with a mode MIC of 0.12 μg/mL and MIC90 of 1 μg/mL, and MIC’s ≥8 μg/mL for B.fragilis and B.vulgatus species, respectively.
Ertapenem sodium (L-749345) is a broad spectrum and long acting β-lactam antibiotic. Ertapenem sodium has a broad-spectrum anti-anaerobic activity against a variety of anaerobes with a mode MIC of 0.12 μg/mL. Ertapenem sodium can be used for the research of severe infections caused by bacteria in the skin, lungs, stomach, pelvis, and urinary tract.
体内研究：
Ertapenem sodium (Subcutaneous injection, 0-10 mg/kg, 0-120 h after infection, S. aureus thigh tissue infection model) shows > 3 log10 CFU reduction of organism at 10 mg/kg, and maintains the activity with 3.3 and 4.4 log10 CFU eliminated at 2 mg/kg.Ertapenem sodium (Subcutaneous injection, 4h after infection, systemic infection model) is active against all gram-positive organisms, and is also active against gram-negative organisms tested with ED50s of3 log10 CFU reduction of organism compared to non-antibiotic-treated controls at 10 mg/kg.Maintained the activity with 3.3 and 4.4 log10 CFU eliminated at 2 mg/kg.
Animal Model:Systemic infection model (DBA/2 female mice, viral antibody-free CD-1 female mice)
Dosage:0-3 mg/kg approximately
Administration:Subcutaneous injection (0.5 mL, begin immediately and 4 h after infection)
Result:Showed activity against all gram-positive organisms, and also ram-negative organisms tested with ED50s of <0.25 mg/kg/dose.
Animal Model:CD-1 mice, rats
Dosage:10 mg/kg approximately
Administration:Intraperitoneal injection (pharmacokinetic assay)
Result:Exhibited an AUC0-∞ ranging from 1.8-21.82 μg?hr/mL in tissue in mice following a 10-mg/kg i.p. dose.Exhibited slow clearance rate with a t1/2β of 3.2 h, Clp of 0.47 mL/min/kg, AUC0-8 of 284.15 μg?hr/mL.
体外研究：
Ertapenem sodium (0-100 μg/mL approximately, 48 h) is active against 99.1% of all anaerobes with a mode MIC of 0.12 μg/mL and MIC90 of 1 μg/mL, and MIC’s ≥8 μg/mL for B.fragilis and B.vulgatus species, respectively.
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