产品
编 号:F181581
分子式:C26H25FN8O4
分子量:532.53
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1mg
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产品详情
生物活性:
Plevitrexed (ZD 9331; BGC 9331) is an orally active and potent thymidylate synthase (TS) inhibitor with a Ki of 0.44 nM. Plevitrexed is taken up via the α-folate receptor as well as the reduced folate carrier. Plevitrexed is used for gastric cancer in clinical. Plevitrexed is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

体外研究:
ZD9331 inhibits the transport of [3H]-methotrexate into L1210 and W1L2 cells with a Ki of~1 μM.
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