产品
编 号：F181528
分子式：C8H3Cl2N3O4
分子量：276.03
分子式：C8H3Cl2N3O4
分子量：276.03
产品类型
规格
价格
是否有货
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
50mg
询价
询价
结构图
CAS No: 153504-81-5
产品详情
生物活性：
Licostinel (ACEA-1021) is a glycine receptor antagonist (IC50: 59 nM). Licostinel has neuroprotective activity.
体内研究：
Animal Model:The permanent model of middle cerebral artery occlusion in fisher 344 rats and CD-1 mice. The transient model of focal ischemia in Wistar and Sprague –Dawley rats[2
Dosage:5 mg/kg bolus 3.5 mg/kg/h for 6h, 10 mg/kg bolus 7.0 mg/kg/h for 6h
Administration:A single intravenous injection bolus continuous infusion
Result:Decreased infarct size.
Animal Model:Male Sprague-Dawley rats
Dosage:20, 40, 80 mg/kg for intraperitoneal injection (i.p.) bolus 7 mg/kg/h , 30mins
Administration:Intravenous injection (i.v.) bolus continuous infusion
Result:Reduced the rate of spreading depression and EEG activity in the rat brain in a dose-dependent manner.
Licostinel (ACEA-1021) is a glycine receptor antagonist (IC50: 59 nM). Licostinel has neuroprotective activity.
体内研究：
Animal Model:The permanent model of middle cerebral artery occlusion in fisher 344 rats and CD-1 mice. The transient model of focal ischemia in Wistar and Sprague –Dawley rats[2
Dosage:5 mg/kg bolus 3.5 mg/kg/h for 6h, 10 mg/kg bolus 7.0 mg/kg/h for 6h
Administration:A single intravenous injection bolus continuous infusion
Result:Decreased infarct size.
Animal Model:Male Sprague-Dawley rats
Dosage:20, 40, 80 mg/kg for intraperitoneal injection (i.p.) bolus 7 mg/kg/h , 30mins
Administration:Intravenous injection (i.v.) bolus continuous infusion
Result:Reduced the rate of spreading depression and EEG activity in the rat brain in a dose-dependent manner.
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