产品
编 号：F181524
分子式：C10H17NOS.HCl.1/2H2O
分子量：244.78
分子式：C10H17NOS.HCl.1/2H2O
分子量：244.78
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
询价
询价
10mg
询价
询价
50mg
询价
询价
结构图
CAS No: 153504-70-2
产品详情
生物活性：
Cevimeline hydrochloride hemihydrate (SNI-2011) is a quinuclidine derivative of acetylcholine and a selective and orally active muscarinic M1 and M3 receptor agonist. Cevimeline hydrochloride hemihydrate stimulates secretion by the salivary glands and can be used as a sialogogue for xerostomia. Cevimeline hydrochloride hemihydrate can cross the blood-brain barrier (BBB).
体内研究：
Cevimeline (0.008-0.016 mg/kg；腹腔注射；雄性 Wistar 大鼠) 处理显示缓慢增加和持久的唾液分泌，以及增加的腮腺血流增量和升压反应。Cevimeline 在 0.016 mg/kg 时抑制血管紧张素 II 诱导的穹隆下器官的水摄入和神经元活动。Animal Model:Male Wistar rats (8-week-old) injected with angiotensin-II
Dosage:0.008 mg/kg, 0.016 mg/kg
Administration:Intraperitoneal injection
Result:Showed slowly increasing and lasting salivation, and increased blood flow increment in the parotid gland and pressor response.
体外研究：
在消化的腮腺细胞中，Cevimeline (0.1-100 μM) 增加细胞内 Ca2+ 浓度。
Cevimeline hydrochloride hemihydrate (SNI-2011) is a quinuclidine derivative of acetylcholine and a selective and orally active muscarinic M1 and M3 receptor agonist. Cevimeline hydrochloride hemihydrate stimulates secretion by the salivary glands and can be used as a sialogogue for xerostomia. Cevimeline hydrochloride hemihydrate can cross the blood-brain barrier (BBB).
体内研究：
Cevimeline (0.008-0.016 mg/kg；腹腔注射；雄性 Wistar 大鼠) 处理显示缓慢增加和持久的唾液分泌，以及增加的腮腺血流增量和升压反应。Cevimeline 在 0.016 mg/kg 时抑制血管紧张素 II 诱导的穹隆下器官的水摄入和神经元活动。Animal Model:Male Wistar rats (8-week-old) injected with angiotensin-II
Dosage:0.008 mg/kg, 0.016 mg/kg
Administration:Intraperitoneal injection
Result:Showed slowly increasing and lasting salivation, and increased blood flow increment in the parotid gland and pressor response.
体外研究：
在消化的腮腺细胞中，Cevimeline (0.1-100 μM) 增加细胞内 Ca2+ 浓度。
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