产品
编 号：F181455
分子式：C32H40ClNO4
分子量：538.12
分子式：C32H40ClNO4
分子量：538.12
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
125
In-stock
5mg
250
In-stock
10mg
400
In-stock
50mg
960
In-stock
100mg
1600
In-stock
结构图
CAS No: 153439-40-8
产品详情
生物活性：
Fexofenadine (MDL-16455) hydrochloride is an orally active and nonsedative H1 receptor antagonist. Fexofenadine hydrochloride can be used in allergic rhinitis and chronic idiopathic urticarial research.
体内研究：
Fexofenadine hydrochloride (oral administration; 5-20 mg/kg; once daily; 3 w) suppresses both eosinophilia and systemic anaphylaxis in C57BL/6 mice infected with T. spiralis.Animal Model:C57BL/6 mice infected with Trichinella spiralis
Dosage:5, 10 and 20 mg/kg
Administration:Oral administration; 5, 10 and 20 mg/kg; once daily; 3 weeks
Result:Inhibited eosinophilia in a dose-dependent manner.Suppressed the decrease in rectal temperature (p<0.01), a marker for systemic anaphylaxis.
体外研究：
Fexofenadine (1-100 μM; 1 h) inhibits the expression of IL-6 protein in nasal fibroblasts in a dose-dependent manner.Fexofenadine (1-100 μM; 1 h) blocks phosphorylated p38 activation in histamine-induced nasal fibroblasts, but shows no effect on either pERK or pJNK.
Fexofenadine (MDL-16455) hydrochloride is an orally active and nonsedative H1 receptor antagonist. Fexofenadine hydrochloride can be used in allergic rhinitis and chronic idiopathic urticarial research.
体内研究：
Fexofenadine hydrochloride (oral administration; 5-20 mg/kg; once daily; 3 w) suppresses both eosinophilia and systemic anaphylaxis in C57BL/6 mice infected with T. spiralis.Animal Model:C57BL/6 mice infected with Trichinella spiralis
Dosage:5, 10 and 20 mg/kg
Administration:Oral administration; 5, 10 and 20 mg/kg; once daily; 3 weeks
Result:Inhibited eosinophilia in a dose-dependent manner.Suppressed the decrease in rectal temperature (p<0.01), a marker for systemic anaphylaxis.
体外研究：
Fexofenadine (1-100 μM; 1 h) inhibits the expression of IL-6 protein in nasal fibroblasts in a dose-dependent manner.Fexofenadine (1-100 μM; 1 h) blocks phosphorylated p38 activation in histamine-induced nasal fibroblasts, but shows no effect on either pERK or pJNK.
产品资料
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