产品
编 号：F181287
分子式：C13H16Cl2N2
分子量：271.19
分子式：C13H16Cl2N2
分子量：271.19
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
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5mg
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10mg
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25mg
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50mg
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100mg
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结构图
CAS No: 153322-06-6
产品详情
生物活性：
Lanicemine (AZD6765) dihydrochloride is a low-trapping NMDA channel blocker (Ki of 0.56-2.1?μM for NMDA receptor; IC50s of 4-7?μM and 6.4 μM in CHO and Xenopus oocyte cells, respectively). Antidepressant effects.
体内研究：
Lanicemine dihydrochloride 具有持续的抗抑郁功效，并且具有最小的拟精神病副作用。Lanicemine dihydrochloride (3、10 或 30 mg/kg；腹膜内注射) 不仅参与生成伽马脑电图 (EEG) 的大脑回路，而且影响这些网络，而不受氯胺酮典型的更广泛的系统级破坏。Animal Model:Male Sprague-Dawley rats
Dosage:3, 10 or 30?mg/kg
Administration:Intraperitoneal
Result:Produced pronounced dose-dependent elevations in spontaneous gamma-band EEG, but only gamma changes for Ketamine were tightly coupled to increases in locomotor activity.
Lanicemine (AZD6765) dihydrochloride is a low-trapping NMDA channel blocker (Ki of 0.56-2.1?μM for NMDA receptor; IC50s of 4-7?μM and 6.4 μM in CHO and Xenopus oocyte cells, respectively). Antidepressant effects.
体内研究：
Lanicemine dihydrochloride 具有持续的抗抑郁功效，并且具有最小的拟精神病副作用。Lanicemine dihydrochloride (3、10 或 30 mg/kg；腹膜内注射) 不仅参与生成伽马脑电图 (EEG) 的大脑回路，而且影响这些网络，而不受氯胺酮典型的更广泛的系统级破坏。Animal Model:Male Sprague-Dawley rats
Dosage:3, 10 or 30?mg/kg
Administration:Intraperitoneal
Result:Produced pronounced dose-dependent elevations in spontaneous gamma-band EEG, but only gamma changes for Ketamine were tightly coupled to increases in locomotor activity.
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