产品
编 号：F181219
分子式：C21H19N3O4S2
分子量：441.52
分子式：C21H19N3O4S2
分子量：441.52
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
836
In-stock
2mg
448
In-stock
5mg
760
In-stock
10mg
1200
In-stock
50mg
3360
In-stock
100mg
4784
In-stock
结构图
CAS No: 1532593-30-8
产品详情
生物活性：
ML355 is a potent and selective inhibitor of 12-Lipoxygenase (12-LOX) with an IC50 of 0.34 μM, shows excellent selectivity over related lipoxygenases and cyclooxygenases, and possesses favorable ADME properties.
体内研究：
ML355 (1.88-30 mg/kg; i.g.; 2 times per day for two days) strongly inhibits the thrombus formation in mice at higher dose compared to WT controls.Animal Model:C57BL/6 mice
Dosage:1.88, 3.75, 7.5, 15, 30 mg/kg
Administration:Oral gavage; 2 times per day for two days
Result:The thrombus formation in mice was strongly inhibited by higher doses of ML355.
体外研究：
ML355 inhibits PAR-4 induced aggregation and calcium mobilization in human platelets and reduce 12-HETE in β-cells.
ML355 is a potent and selective inhibitor of 12-Lipoxygenase (12-LOX) with an IC50 of 0.34 μM, shows excellent selectivity over related lipoxygenases and cyclooxygenases, and possesses favorable ADME properties.
体内研究：
ML355 (1.88-30 mg/kg; i.g.; 2 times per day for two days) strongly inhibits the thrombus formation in mice at higher dose compared to WT controls.Animal Model:C57BL/6 mice
Dosage:1.88, 3.75, 7.5, 15, 30 mg/kg
Administration:Oral gavage; 2 times per day for two days
Result:The thrombus formation in mice was strongly inhibited by higher doses of ML355.
体外研究：
ML355 inhibits PAR-4 induced aggregation and calcium mobilization in human platelets and reduce 12-HETE in β-cells.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备