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编 号：F181181
分子式：C21H26N2O6S
分子量：434.51
分子式：C21H26N2O6S
分子量：434.51
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CAS No: 153230-94-5
产品详情
生物活性：
Catharanthine ((+)-3,4-Didehydrocoronaridine) Sulfate, a constituent of anticancer vinca alkaloids, inhibits voltage-operated L-type Ca2+ channel (VOCC). Catharanthine Sulfate has IC50s of 220 μM and 8 μM for VOCC currents in cardiomyocytes and vascular smooth muscle cells (VSMCs), respectively. Catharanthine Sulfate lowers blood pressure (BP), heart rate (HR). Catharanthine Sulfate has anti-cancer activity.
体内研究：
Catharanthine ((+)-3,4-Didehydrocoronaridine；0.5-20 mg/kg；静脉给药；单剂量) Sulfate 可引起血压和心率的剂量依赖性降低。Catharanthine (40 mg/kg；腹腔注射；单剂量) Sulfate 急性给药在 1 小时和 24 小时在雄性和雌性小鼠中诱导类似的抗抑郁样活性。Catharanthine (20 mg/kg；腹腔注射；连续 14 天) Sulfate 在 D7 或 D14 增加小鼠游泳时间并减少不动时间。Animal Model:13-week-old male SpragueDawley rats (300-350 g)
Dosage:0.5-20 mg/kg
Administration:IV; single dose
Result:Evoked rapid, transient reductions in BP and HR (lasting ,2 minutes) at low doses (0.5–5 mg/kg), whereas at higher doses (10 and 20 mg/kg), the BP and HR reductions were sustained.
Catharanthine ((+)-3,4-Didehydrocoronaridine) Sulfate, a constituent of anticancer vinca alkaloids, inhibits voltage-operated L-type Ca2+ channel (VOCC). Catharanthine Sulfate has IC50s of 220 μM and 8 μM for VOCC currents in cardiomyocytes and vascular smooth muscle cells (VSMCs), respectively. Catharanthine Sulfate lowers blood pressure (BP), heart rate (HR). Catharanthine Sulfate has anti-cancer activity.
体内研究：
Catharanthine ((+)-3,4-Didehydrocoronaridine；0.5-20 mg/kg；静脉给药；单剂量) Sulfate 可引起血压和心率的剂量依赖性降低。Catharanthine (40 mg/kg；腹腔注射；单剂量) Sulfate 急性给药在 1 小时和 24 小时在雄性和雌性小鼠中诱导类似的抗抑郁样活性。Catharanthine (20 mg/kg；腹腔注射；连续 14 天) Sulfate 在 D7 或 D14 增加小鼠游泳时间并减少不动时间。Animal Model:13-week-old male SpragueDawley rats (300-350 g)
Dosage:0.5-20 mg/kg
Administration:IV; single dose
Result:Evoked rapid, transient reductions in BP and HR (lasting ,2 minutes) at low doses (0.5–5 mg/kg), whereas at higher doses (10 and 20 mg/kg), the BP and HR reductions were sustained.
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