产品
编 号：F181141
分子式：C41H54N6O6
分子量：726.9
分子式：C41H54N6O6
分子量：726.9
产品类型
规格
价格
是否有货
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
结构图
CAS No: 153190-29-5
产品详情
生物活性：
U-74389G (PNU74389G meleate) is an antioxidant, can inhibit lipid peroxidation reactions. U-74389G can protect against ischemia-reperfusion injury and be widely used in animal models of ischemic injury and hypertension. U-74389G shows anti-inflammatory activity.
体内研究：
U-74389G (intravenous injection; 10 mg/kg; once daily; 6 d) treatment shows significant anti-inflammatory activity related to its ability to reduce colonic TNF-α, CMDI score, and improve weight change.U-74389G (intravenous injection; 15 or 30 mg/kg) treatment significantly protects against lipopolysaccharide-induced lethality, reduces hypotension, ameliorates liver function, decreases plasma nitrite levels, restores the hyporeactivity of aortic rings to their control values and inhibits the activity of inducible NO synthase in the liver and in the aorta.Animal Model:Rat model of trinitrobenzenesulfonic acid-induced colitis
Dosage:10 mg/kg
Administration:Intravenous injection; 10 mg/kg; once daily; 6 d
Result:Reduced TNF-α, the macroscopic index of mucosal damage score (CMDI) and increased body weight.
Animal Model:Male Sprague–Dawley rats injected with Lipopolysaccharide
Dosage:15 or 30 mg/kg
Administration:Intravenous injection; 15 or 30 mg/kg
Result:Protected against lipopolysaccharide-induced lethality (90% survival rate 24 h and 80% 72 h after Lipopolysaccharide injection, respectively, following the highest dose).
体外研究：
U-74389G (12.5, 25 and 50 μM; 24 h) inhibits nitrite production in endotoxin stimulated peritoneal macrophages.
U-74389G (PNU74389G meleate) is an antioxidant, can inhibit lipid peroxidation reactions. U-74389G can protect against ischemia-reperfusion injury and be widely used in animal models of ischemic injury and hypertension. U-74389G shows anti-inflammatory activity.
体内研究：
U-74389G (intravenous injection; 10 mg/kg; once daily; 6 d) treatment shows significant anti-inflammatory activity related to its ability to reduce colonic TNF-α, CMDI score, and improve weight change.U-74389G (intravenous injection; 15 or 30 mg/kg) treatment significantly protects against lipopolysaccharide-induced lethality, reduces hypotension, ameliorates liver function, decreases plasma nitrite levels, restores the hyporeactivity of aortic rings to their control values and inhibits the activity of inducible NO synthase in the liver and in the aorta.Animal Model:Rat model of trinitrobenzenesulfonic acid-induced colitis
Dosage:10 mg/kg
Administration:Intravenous injection; 10 mg/kg; once daily; 6 d
Result:Reduced TNF-α, the macroscopic index of mucosal damage score (CMDI) and increased body weight.
Animal Model:Male Sprague–Dawley rats injected with Lipopolysaccharide
Dosage:15 or 30 mg/kg
Administration:Intravenous injection; 15 or 30 mg/kg
Result:Protected against lipopolysaccharide-induced lethality (90% survival rate 24 h and 80% 72 h after Lipopolysaccharide injection, respectively, following the highest dose).
体外研究：
U-74389G (12.5, 25 and 50 μM; 24 h) inhibits nitrite production in endotoxin stimulated peritoneal macrophages.
产品资料
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