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编 号：F020323
分子式：C31H36N2O2
分子量：468.63
分子式：C31H36N2O2
分子量：468.63
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CAS No: 1048039-15-1
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生物活性：
COR170 (11u) is a selective CB2 inverse-agonist which is a 4-quinolone-3-carboxylic acid derivative with a Ki value of 3.8 nM for CB2 receptor. COR170 can be used for the research of inflammation and neuroprotection.
体内研究：
COR170 (11u) (1.5-6 mg/kg; i.p, once) reduces the late phase nociceptive behaviour induced by formalin.Animal Model:Mice with formalin (1.25%, 30 μL) injections
Dosage:1.5, 3 and 6 mg/kg
Administration:Intraperitoneal injection; 1.5, 3 and 6 mg/kg for once
Result:Reduced the late phase nociceptive behaviour induced by formalin with a 6 mg/kg dose and 10 min before formalin and abolished the analgesic effect from GW405833 which is a CB2 receptor partial agonist.
体外研究：
COR170 (11u) (0-1 μM) inhibits CB2 receptor in HEK cell membranes with a Ki value of 3.8 nM.
COR170 (11u) is a selective CB2 inverse-agonist which is a 4-quinolone-3-carboxylic acid derivative with a Ki value of 3.8 nM for CB2 receptor. COR170 can be used for the research of inflammation and neuroprotection.
体内研究：
COR170 (11u) (1.5-6 mg/kg; i.p, once) reduces the late phase nociceptive behaviour induced by formalin.Animal Model:Mice with formalin (1.25%, 30 μL) injections
Dosage:1.5, 3 and 6 mg/kg
Administration:Intraperitoneal injection; 1.5, 3 and 6 mg/kg for once
Result:Reduced the late phase nociceptive behaviour induced by formalin with a 6 mg/kg dose and 10 min before formalin and abolished the analgesic effect from GW405833 which is a CB2 receptor partial agonist.
体外研究：
COR170 (11u) (0-1 μM) inhibits CB2 receptor in HEK cell membranes with a Ki value of 3.8 nM.
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