产品
编 号：F180797
分子式：C20H24O10
分子量：424.4
分子式：C20H24O10
分子量：424.4
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
25mg
560
In-stock
50mg
960
In-stock
100mg
1440
In-stock
结构图
CAS No: 15291-77-7
产品详情
生物活性：
Ginkgolide B (BN-52021), a terpene lactone, is a potent platelet activating factor antagonist. Ginkgolide B protects endothelial cells via the activation of PXR from injuries induced by xeno- and endobiotics. Ginkgolide B can pass through the brain-blood barrier. Ginkgolide B has anti-oxidant, anti-inflammatory, anti-tumor, and anti-apoptotic activity. Ginkgolide B has marked neuroprotective effects against ischemia-induced impairments.
体内研究：
Ginkgolide B (BN-52021；20 mg/kg；腹膜内注射；缺血后立即和 6 小时，此后每天一次；14 天) 可降低神经功能缺损评分。Animal Model:Male clean healthy Sprague-Dawley rats, weighing 250-280 g and aged 8 weeks
Dosage:20 mg/kg
Administration:Intraperitoneally; immediately and 6 hours after ischemia, and thereafter once daily; 14 days
Result:Decreased the neurological deficit score, increased the proportion of nestin-, neuron-specific enolase- and glial fibrillary acid protein-positive cells. Caused down-regulation of NSE protein at day 14.
体外研究：
Ginkgolide B (BN-52021；30-150 μM；24 小时) 抑制 TNF-α (10 ng/mL) 诱导的 VCAM-1 和 E-selectin 蛋白表达上调。Ginkgolide B (30-150 μM；24、48 小时) 可增加 CYP3A4 mRNA 和 MDR1 表达。Ginkgolide B (30-150 μM；预处理 24 小时) 与阳性对照相比，可减少 Staurosporine (500 nM；6 小时) 诱导的细胞凋亡，与阴性对照相比，其表现出明显的细胞凋亡。Ginkgolide B 不会影响 Doxorubicin (5 μM；24 小时) 诱导的细胞凋亡。Ginkgolide B 调节 PXR 活性，但不影响 PXR 表达。
Ginkgolide B (BN-52021), a terpene lactone, is a potent platelet activating factor antagonist. Ginkgolide B protects endothelial cells via the activation of PXR from injuries induced by xeno- and endobiotics. Ginkgolide B can pass through the brain-blood barrier. Ginkgolide B has anti-oxidant, anti-inflammatory, anti-tumor, and anti-apoptotic activity. Ginkgolide B has marked neuroprotective effects against ischemia-induced impairments.
体内研究：
Ginkgolide B (BN-52021；20 mg/kg；腹膜内注射；缺血后立即和 6 小时，此后每天一次；14 天) 可降低神经功能缺损评分。Animal Model:Male clean healthy Sprague-Dawley rats, weighing 250-280 g and aged 8 weeks
Dosage:20 mg/kg
Administration:Intraperitoneally; immediately and 6 hours after ischemia, and thereafter once daily; 14 days
Result:Decreased the neurological deficit score, increased the proportion of nestin-, neuron-specific enolase- and glial fibrillary acid protein-positive cells. Caused down-regulation of NSE protein at day 14.
体外研究：
Ginkgolide B (BN-52021；30-150 μM；24 小时) 抑制 TNF-α (10 ng/mL) 诱导的 VCAM-1 和 E-selectin 蛋白表达上调。Ginkgolide B (30-150 μM；24、48 小时) 可增加 CYP3A4 mRNA 和 MDR1 表达。Ginkgolide B (30-150 μM；预处理 24 小时) 与阳性对照相比，可减少 Staurosporine (500 nM；6 小时) 诱导的细胞凋亡，与阴性对照相比，其表现出明显的细胞凋亡。Ginkgolide B 不会影响 Doxorubicin (5 μM；24 小时) 诱导的细胞凋亡。Ginkgolide B 调节 PXR 活性，但不影响 PXR 表达。
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