产品
编 号：F180686
分子式：C17H12Br2O4
分子量：440.08
分子式：C17H12Br2O4
分子量：440.08
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 152831-00-0
产品详情
生物活性：
6-Hydroxybenzbromarone is the?major metabolite of Benzbromarone with a longer half-life and greater pharmacological potency than the parent compound.?6-Hydroxybenzbromarone is a?protein Eyes Absent 3 (EYA3) inhibitor with an IC50 value of 21.5 μM.?6-Hydroxybenzbromarone is an?anti-angiogenic agent,?has strong?inhibitory effects on cell migration, tubulogenesis, and angiogenic sprouting.
体外研究：
6-Hydroxybenzbromarone (7.5 μM; 72 hours) shows over 50% reduction in cell proliferation. Meanwhile, treatment with BBR and BZ also reduces cell viability, but none of the other compounds tested has a negative impact on cell viability or proliferation.6-Hydroxybenzbromarone (7.5 μM; 1-20 hours) has inhibitory affects EC migration tubulogenesis of HUVECs. However, the effect of 6OH-BBR on tube formation is attenuated in the presence of high concentrations of fetal bovine serum (FBS), likely reflecting non-specific protein binding.
6-Hydroxybenzbromarone is the?major metabolite of Benzbromarone with a longer half-life and greater pharmacological potency than the parent compound.?6-Hydroxybenzbromarone is a?protein Eyes Absent 3 (EYA3) inhibitor with an IC50 value of 21.5 μM.?6-Hydroxybenzbromarone is an?anti-angiogenic agent,?has strong?inhibitory effects on cell migration, tubulogenesis, and angiogenic sprouting.
体外研究：
6-Hydroxybenzbromarone (7.5 μM; 72 hours) shows over 50% reduction in cell proliferation. Meanwhile, treatment with BBR and BZ also reduces cell viability, but none of the other compounds tested has a negative impact on cell viability or proliferation.6-Hydroxybenzbromarone (7.5 μM; 1-20 hours) has inhibitory affects EC migration tubulogenesis of HUVECs. However, the effect of 6OH-BBR on tube formation is attenuated in the presence of high concentrations of fetal bovine serum (FBS), likely reflecting non-specific protein binding.
产品资料
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